Release of atrial natriuretic peptide by atrial distension.
Release of atrial natriuretic peptide by atrial distension.
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心房扩张释放心房钠尿肽。
DOI：
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发表时间：
1985
影响因子：
2.1
通讯作者：
A. Rankin
中科院分区：
文献类型：
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作者：
J. R. Ledsome;N. Wilson;C. Courneya;A. Rankin
用异源放射免疫法测定了8只氯醛糖麻醉犬股动脉血浆中免疫反应性心钠素（iANP）的浓度。二尖瓣阻塞使左心房压力增加11 cmH 2 O，使血浆iANP从97 +/- 10.3（平均值+/- SE）增加至135 +/- 14.3 pg/mL。肺静脉扩张增加心率，但不增加血浆iANP。双侧颈迷走神经切断术和阿替洛尔（2 mg/kg）给药并不能阻止二尖瓣阻塞时iANP的增加。来自冠状窦的血液样品的血浆iANP显著高于来自股动脉的同时样品，证实了iANP的心脏来源。iANP的释放依赖于心房的直接牵拉，而不是涉及左心房受体的反射。
A heterologous radioimmunoassay was used to measure the concentration of immunoreactive atrial natriuretic peptide (iANP) in plasma from the femoral artery of eight chloralose anaesthetized dogs. Mitral obstruction which increased left atrial pressure by 11 cmH2O increased plasma iANP from 97 +/- 10.3 (mean +/- SE) to 135 +/- 14.3 pg/mL. Pulmonary vein distension increased heart rate but did not increase plasma iANP. Bilateral cervical vagotomy and administration of atenolol (2 mg/kg) did not prevent the increase in iANP with mitral obstruction. Samples of blood from the coronary sinus had plasma iANP significantly higher than simultaneous samples from the femoral artery confirming the cardiac origin of the iANP. Release of iANP depends on direct stretch of the atrium rather than on a reflex involving left atrial receptors.