ROLE OF EPISTASIS AND OVERDOMINANCE IN STABILITY OF EQUILIBRIA WITH SELECTION
ROLE OF EPISTASIS AND OVERDOMINANCE IN STABILITY OF EQUILIBRIA WITH SELECTION
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DOI：
10.1073/pnas.45.7.984
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发表时间：
1959-01-01
影响因子：
11.1
通讯作者：
KOJIMA, KI
中科院分区：
文献类型：
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作者：
KOJIMA, KI
当基因表现出上位性时，假设每个基因座有2个等位基因、基因型值恒定、自由重组和随机交配，稳定平衡的条件是在两个基因座中的每一个都发生超显性，并且来自每个基因座的显性方差的几何平均值大于两个基因座的加性×加性方差。对于多于两个基因座的情况，假设所有基因座在平衡时具有相等的效应和相同的基因频率，更多的显性倾向于维持稳定平衡，而更多的加性×加性上位性倾向于破坏稳定平衡。
The conditions for stable equilibria when genes exhibit epistasis, assuming 2 alleles per locus, constant genotype values, free recombination and random mating, are that overdominance occurs at each of the two loci, and that the geometric mean of the dominance variances from each locus be larger than the additive X additive variance for 2 loci. For more than 2 loci, assuming that all loci have equal effects and the same gene frequencies at equilibrium more dominance tends to maintain stable equilibria while more additive X additive epistasis tends to destroy stable equilibria.