Functions of polyphenols and its anticancer properties in biomedical research: a narrative review.
Functions of polyphenols and its anticancer properties in biomedical research: a narrative review.
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多酚及其在生物医学研究中的抗癌特性的功能：叙事评论。
DOI：
10.21037/tcr-20-2359
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发表时间：
2020-12
影响因子：
0.9
通讯作者：
Kim GS
中科院分区：
文献类型：
--
作者：
Bhosale PB;Ha SE;Vetrivel P;Kim HH;Kim SM;Kim GS
癌症是全球范围内的主要关注点，并且缺乏植物性的功能性食品。截至2020年6月，电子数据库PubMed，带有以下关键词 - 多酚，多酚抗癌，槲皮素抗癌，白藜芦醇抗癌，姜黄素抗癌药和kaempferol抗体剂的capers paper limate 5。多酚和癌症，987槲皮素癌症和癌症的癌症和癌症有2,174个，有1,079个白藜芦醇和癌症，以及226次癌症限制为kaempferol和癌症，其中包括大多数综合研究的论文。多酚时的协同作用Treatment combined with chemotherapeutic agents. Anticancer effects of polyphenol compounds like quercetin, curcumin, resveratrol, and kaempferol are investigated on numerous cancer cell lines and have shown prominent results. The present review provides a direction to determine the anticarcinogenic ability of the selected polyphenols in vitro and in vivo. Consequently, the use of polyphenols in cancer treatment should be investigated in-depth in the future.
Cancer is a major health concern as the incidence is growing worldwide and still lacks successful therapies. Plant-derived functional foods are getting considerable attention, primarily due to their safety and therapeutic potential. Polyphenols are a group of mostly natural, water-soluble organic compounds. Here, we review the functions of selected polyphenols and their anticancer properties on numerous cancer cell lines and their mechanisms. The literature search was performed using the electronic database PubMed, Google scholar up to June 2020, with the following keywords—polyphenol, polyphenol anticancer, quercetin anticancer, resveratrol anticancer, curcumin anticancer, and kaempferol anticancer. Chemical structures of the selected polyphenols were obtained using the ChemDraw program. The initial search identified 40,554 polyphenols papers and among that, 2,559 were limited to polyphenol and cancer, 987 quercetin and cancer, 2,174 curcumin and cancer, 1,079 resveratrol and cancer, and 226 were limited to kaempferol and cancer. A total of 84 papers are included in this review paper. Most studies report the multiple anticarcinogenic properties of plant-derived polyphenols, including its inhibitory effects on the proliferation of cancer cells, tumor expansion, angiogenesis, inflammation, and metastasis. Besides, some studies shows potential synergistic effects when polyphenol treatment combined with chemotherapeutic agents. Anticancer effects of polyphenolic compounds like quercetin, curcumin, resveratrol, and kaempferol are investigated on numerous cancer cell lines and have shown prominent results. The present review provides a direction to determine the anticarcinogenic ability of the selected polyphenols in vitro and in vivo. Consequently, the use of polyphenols in cancer treatment should be investigated in-depth in the future.
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影响因子：
1.7
作者：
Cao, Ai-Li;Tang, Qing-Feng;Yin, Pei-Hao
通讯作者：
Yin, Pei-Hao
影响因子：
4.2
作者：
Chen, Hui-Jye;Lin, Chung-Ming;Yang, Jai-Sing
通讯作者：
Yang, Jai-Sing
影响因子：
5.6
作者：
Granato, Marisa;Rizzello, Celeste;Cirone, Mara
通讯作者：
Cirone, Mara
DOI：
10.1080/01635581.2012.717677
发表时间：
2012-01-01
影响因子：
2.9
作者：
Christensen, Krista Yorita;Naidu, Adonia;Koushik, Anita
通讯作者：
Koushik, Anita
DOI：
10.1111/j.1749-6632.2002.tb02918.x
发表时间：
2002-01-01
期刊：
ALCOHOL AND WINE IN HEALTH AND DISEASE
影响因子：
--
作者：
Bhat, KPL;Pezzuto, JM
通讯作者：
Pezzuto, JM