Poor creativity in frontotemporal dementia: A window into the neural bases of the creative mind
Poor creativity in frontotemporal dementia: A window into the neural bases of the creative mind
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DOI：
10.1016/j.neuropsychologia.2010.09.010
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发表时间：
2010-11-01
期刊：
影响因子：
2.6
通讯作者：
Levy, Richard
中科院分区：
文献类型：
--
作者：
de Souza, Leonardo Cruz;Volle, Emmanuelle;Levy, Richard
背景：前额叶皮层（PFC）支持创造性思维的关键功能。对PFC的损伤预计会削弱创造力。然而，先前的研究表明，额颞叶变性（FTLD）患者出现了艺术天赋，这被解释为创造力的增加。目的：我们设计了一项FTLD额叶变异（fv）患者的研究，以验证：(1)创造力在额叶变性后是否受损，(2)创造力差与额叶功能障碍有关，(3)创造力差与特定PFC区域灌注不足有关。材料与方法：研究对象分为三组：fvFTLD患者（n = 17）、非痴呆性帕金森病（PD）患者（n = 12）和健康对照（n = 17）。参与者进行了标准化的创造力测试，即托伦斯创造性思维测试（Tro-）和评估额叶功能的测试。脑灌注与fvFTLD患者在TTCT中的表现相关。结果：与PD患者和对照组相比，fvFTLD患者在TTCT的所有维度上都受到严重损害。仅在fvFTLD患者中观察到解除抑制和持续反应，导致“伪创造性”反应。创造力低下与多项正面测试呈正相关。创造力低下也与前额叶灌注不足有关，尤其是在额极。结论：创造力低下与fvFTLD有关。研究结果还表明，PFC的完整性（尤其是额极区）与创造性思维密切相关。fvFTLD患者出现艺术天赋的原因是无意识行为的释放，而不是创造性思维的发展。(C) 2010 Elsevier Ltd.版权所有。
Background: The prefrontal cortex (PFC) supports functions critical for creative thinking. Damage to the PFC is expected to impair creativity. Yet, previous works suggested the emergence of artistic talent in patients with frontotemporal lobar degeneration (FTLD), which was interpreted as increased creativity.Objective: We designed a study in patients with frontal variant (fv) of FTLD in order to verify whether: (1) creativity is impaired after frontal degeneration, (2) poor creativity is associated with frontal dysfunctions, and (3) poor creativity is related to hypoperfusion in specific PFC regions.Materials and methods: Three groups of subjects were enrolled in the study: fvFTLD patients (n = 17), non-demented Parkinson's disease (PD) patients (n = 12) and healthy controls (n = 17). Participants performed a standardized test of creativity, the Torrance Test of Creative Thinking (Tro-) and tests assessing frontal functions. Brain perfusion was correlated to fvFTLD patients' performance in the TTCT.Results: Patients with fvFTLD were strongly impaired in all dimensions of the TTCT, compared to PD patients and controls. Disinhibited and perseverative responses were observed only in fvFTLD patients, leading to "pseudo-creative" responses. Poor creativity was positively correlated with several frontal tests. Poor creativity was also correlated with prefrontal hypoperfusion, particularly in the frontal pole.Conclusions: Poor creativity is associated with fvFTLD. The results also suggest that the integrity of the PFC (in particular frontopolar) is strongly associated with creative thinking. The emergence of artistic talent in patients with fvFTLD is explained by the release of involuntary behaviors, rather than by the development of creative thinking. (C) 2010 Elsevier Ltd. All rights reserved.