The role of B27 heavy chain dimer immune receptor interactions in spondyloarthritis.
The role of B27 heavy chain dimer immune receptor interactions in spondyloarthritis.
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DOI：
10.1007/978-1-4419-0298-6_21
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发表时间：
2009
影响因子：
--
通讯作者：
S. Kollnberger;P. Bowness
中科院分区：
文献类型：
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作者：
S. Kollnberger;P. Bowness
HLA-B27（B27）与脊柱关节病密切相关。B27的经典作用是将来自细胞内病原体的肽呈递为与β2微球蛋白的异源三聚体复合物，以供CD 8 T细胞的T细胞受体（TCR）识别。除异源三聚体外，B27还可表达为细胞表面无β 2-微球蛋白（β 2 m）的同源二聚体（B272）。除了TCR之外，MHC I类分子结合免疫调节受体，包括杀伤免疫球蛋白样受体（KIR）和白细胞免疫球蛋白样受体（LILR）家族的成员。啮齿动物表达与LILR相关的成对免疫球蛋白受体（PIR）家族。B272而非β 2 m相关B27结合KIR 3DL 2和啮齿动物PIR。表达与B272相互作用的免疫受体KIR 3DL 2的NK和T细胞在B27 AS患者中扩增。B272与免疫受体的连接促进表达KIR的白细胞的存活并调节免疫细胞因子的产生。B272在脊柱关节炎中的表达上调以及β 2 m相关的HLA-B27和B272与免疫受体的差异性相互作用可能参与了B27相关性脊柱关节炎（AS）的发病机制。
HLA-B27 (B27) is strongly associated with spondyloarthopathy. The classical role of B27 is to present peptides from intracellular pathogens as a heterotrimeric complex with β2 microglobulin for recognition by the T-cell receptor (TCR) of CD8 T-cells. In addition to heterotrimers, B27 can also be expressed as cell surface beta2-microglobulin (β2m)-free homodimers (B272). In addition to the TCR, MHC class I molecules bind to immunoregulatory receptors including members of the killer immunoglobulin-like receptor (KIR) and leukocyte immunoglobulin-like receptor (LILR) families. Rodents express the paired immunoglobulin receptor (PIR) family which are related to LILR. B272but not β2m-associated B27 binds to KIR3DL2 and rodent PIR. NK and T-cells expressing the immune receptor KIR3DL2, which interacts with B272, are expanded in B27 AS patients. Ligation of immune receptors by B272promotes the survival of KIR-expressing leukocytes and modulates immune cytokine production. Upregulation of B272in spondyloarthritis and differential interaction of β2m-associated HLA-B27 and B272with immune receptors could be involved in the pathogenesis of B27-associated spondyloarthritis (AS).