Association of visceral adiposity with oesophageal and junctional adenocarcinomas
Association of visceral adiposity with oesophageal and junctional adenocarcinomas
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DOI：
10.1002/bjs.7100
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发表时间：
2010-07-01
影响因子：
9.6
通讯作者：
Keogan, M. T.
中科院分区：
文献类型：
--
作者：
Beddy, P.;Howard, J.;Keogan, M. T.
背景资料：肥胖与食管和食管胃交界处腺癌的发病率增加有关，特别是Siewert I型和II型。本研究比较了食管/交界腺癌患者与食管鳞状细胞癌和胃腺癌患者以及对照组的腹部脂肪组成。方法：共招募了194例患者（110例食管/交界腺癌、38例胃腺癌和46例食管鳞状细胞癌）和90名匹配的对照受试者。采用CT测量腹部脂肪面积，计算总脂肪面积（TFA）、内脏脂肪面积（VFA）和皮下脂肪面积（SFA）。食管/交界腺癌患者的TFA和VFA值显著高于对照组胃腺癌组（P = 0.013，P = 0.006）和食管鳞癌组（P均< 0.001）。对于交界性肿瘤，Siewert I型肿瘤患者的TFA和VFA值最高（分别为P = 0.041和P = 0.033对III型; P = 0.332和P = 0.152对II型）。食管/交界腺癌患者，特别是食管和Siewert I型交界肿瘤，与胃腺癌或食管鳞状细胞癌患者或对照组相比，有更大的CT定义的内脏肥胖。
Background: Obesity is associated with an increased incidence of oesophageal and oesophagogastric junction adenocarcinoma, in particular Siewert types I and II. This study compared abdominal fat composition in patients with oesophageal/junctional adenocarcinoma with that in patients with oesophageal squamous cell carcinoma and gastric adenocarcinoma, and in controls.Method: In total, 194 patients (110 with oesophageal/junctional adenocarcinoma, 38 with gastric adenocarcinoma and 46 with oesophageal squamous cell carcinoma) and 90 matched control subjects were recruited. The abdominal fat area was assessed using computed tomography (CT), and the total fat area (TFA), visceral fat area (VFA) and subcutaneous fat area (SFA) were calculated.Results: Patients with oesophageal/junctional adenocarcinoma had significantly higher TFA and VFA values compared with controls (both P < 0.001), patients with gastric adenocarcinoma (P = 0.013 and P = 0.006 respectively) and patients with oesophageal squamous cell carcinoma (both P < 0.001). For junctional tumours, the highest TFA and VFA values were seen in patients with Siewert type I tumours (respectively P = 0.041 and P = 0.033 versus type III; P = 0.332 and P = 0.152 versus type II).Conclusion: Patients with oesophageal/junctional adenocarcinoma, in particular oesophageal and Siewert type I junctional tumours, have greater CT-defined visceral adiposity than patients with gastric adenocarcinoma or oesophageal squamous cell carcinoma, or controls.