ANTI-ONCOGENIC AND ONCOGENIC POTENTIALS OF INTERFERON REGULATORY FACTOR-I AND FACTOR-II
ANTI-ONCOGENIC AND ONCOGENIC POTENTIALS OF INTERFERON REGULATORY FACTOR-I AND FACTOR-II
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DOI：
10.1126/science.8438157
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发表时间：
1993-02-12
期刊：
影响因子：
56.9
通讯作者：
TANIGUCHI, T
中科院分区：
文献类型：
--
作者：
HARADA, H;KITAGAWA, M;TANIGUCHI, T
干扰素调节因子-1 （IRF-1）是一种转录激活因子，IRF-2是其拮抗抑制因子，已被确定为I型干扰素和干扰素诱导基因的调节因子。IRF-1基因本身是干扰素诱导的，因此可能是干扰素作用的关键靶基因之一。当IRF-2基因在NIH 3T3细胞中过表达时，细胞在裸鼠中转化并表现出增强的致瘤性。这种转化的表型被IRF-1基因的同时过表达逆转。因此，受抑制的细胞生长取决于这两个相互拮抗的转录因子之间的平衡。
Interferon regulatory factor-1 (IRF-1), a transcriptional activator, and IRF-2, its antagonistic repressor, have been identified as regulators of type I interferon and interferon-inducible genes. The IRF-1 gene is itself interferon-inducible and hence may be one of the target genes critical for interferon action. When the IRF-2 gene was overexpressed in NIH 3T3 cells, the cells became transformed and displayed enhanced tumorigenicity in nude mice. This transformed phenotype was reversed by concomitant overexpression of the IRF-1 gene. Thus, restrained cell growth depends on a balance between these two mutually antagonistic transcription factors.