Synthetic approaches to selenacephams and selenacephems via a cleavage of diselenide and selenium anion
Synthetic approaches to selenacephams and selenacephems via a cleavage of diselenide and selenium anion
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DOI：
10.1039/c0nj00782j
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发表时间：
2011-01-01
影响因子：
3.3
通讯作者：
Koketsu, Mamoru
中科院分区：
文献类型：
--
作者：
Garud, Dinesh R.;Makimura, Masaki;Koketsu, Mamoru
合成了双-2-（三甲基硅基）乙基二硒醚，并将其用作硒化试剂，用于在氮杂环丁烷酮的C-4位插入2-（三甲基硅基）乙基硒基。双-4-（氮杂环丁烷-2-酮）二硒醚首次被用作合成含硒β-内酰胺类化合物（即硒乙酰芬和硒乙酰芬）的关键中间体。
The bis-2-(trimethylsilyl) ethyl diselenide was prepared and used as a selenating reagent for the insertion of the 2-(trimethylsilyl)ethylseleno group at the C-4 position of the azetidinones. Bis-4-(azetidin-2-one) diselenides were used for the first time as a key intermediate for the synthesis of selenium-containing beta-lactams i.e. selenacephams and selenacephems.