Neuropharmacology of Sleep and Wakefulness.
Neuropharmacology of Sleep and Wakefulness.
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DOI：
10.1016/j.jsmc.2010.08.003
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发表时间：
2010-12
影响因子：
2.8
通讯作者：
Lydic, Ralph
中科院分区：
文献类型：
--
作者：
Watson, Christopher J;Baghdoyan, Helen A;Lydic, Ralph
镇静剂/催眠药分子的发展一直是经验性的，而不是理性的。经验法已经产生了临床上有用的药物，但对任何药物的作用机制都不完全了解。所有可用的镇静剂/催眠药都有不想要的副作用，这些药物都没有创造出与自然睡眠完全相同的睡眠结构。本章综述了最近的研究进展，旨在阐明调节睡眠和觉醒的神经化学机制。合理药物设计的一个希望是，了解镇静/催眠作用的机制将显著提高药物的安全性和有效性。
The development of sedative/hypnotic molecules has been empiric rather than rational. The empiric approach has produced clinically useful drugs but for no drug is the mechanism of action completely understood. All available sedative/hypnotic medications have unwanted side effects and none of these medications creates a sleep architecture that is identical to the architecture of naturally occurring sleep. This chapter reviews recent advances in research aiming to elucidate the neurochemical mechanisms regulating sleep and wakefulness. One promise of rational drug design is that understanding the mechanisms of sedative/hypnotic action will significantly enhance drug safety and efficacy.