Rapid Re-Infection with Soil-Transmitted Helminths after Triple-Dose Albendazole Treatment of School-Aged Children in Yunnan, People's Republic of China
Rapid Re-Infection with Soil-Transmitted Helminths after Triple-Dose Albendazole Treatment of School-Aged Children in Yunnan, People's Republic of China
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DOI：
10.4269/ajtmh.13-0009
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发表时间：
2013-07-01
影响因子：
3.3
通讯作者：
Steinmann, Peter
中科院分区：
文献类型：
--
作者：
Yap, Peiling;Du, Zun-Wei;Steinmann, Peter
作为一项随机对照试验的一部分，对中华人民共和国云南省少数民族学龄儿童进行了治疗后土源性蠕虫再次感染模式的研究。患有土源性蠕虫感染的儿童 (N = 194) 被随机分配到三剂量阿苯达唑或安慰剂组，并使用 Kato-Katz 和 Baermann 技术在 6 个月的时间内监测他们的感染状态。鞭虫、蛔虫、钩虫和粪类圆线虫的基线患病率分别为 94.5%、93.3%、61.3% 和 3.1%，超过一半的参与者携带三种感染。对于干预组（N = 99），治疗后 1 个月钩虫、蚓状线虫和毛线虫的治愈率分别为 96.7%、91.5% 和 19.6%。所有三个物种的产卵率均超过 88%。观察到蛔虫快速再次感染：治疗后 4 个月和 6 个月的患病率分别为 75.8% 和 83.8%。钩虫和毛线虫的再次感染速度要慢得多。
Post-treatment soil-transmitted helminth re-infection patterns were studied as part of a randomized controlled trial among school-aged children from an ethnic minority group in Yunnan province, People's Republic of China. Children with a soil-transmitted helminth infection (N = 194) were randomly assigned to triple-dose albendazole or placebo and their infection status monitored over a 6-month period using the Kato-Katz and Baermann techniques. Baseline prevalence of Trichuris trichiura, Ascaris lumbricoides, hookworm, and Strongyloides stercoralis were 94.5%, 93.3%, 61.3%, and 3.1%, respectively, with more than half of the participants harboring triple-species infections. For the intervention group (N = 99), the 1-month post-treatment cure rates were 96.7%, 91.5%, and 19.6% for hookworm, A. lumbricoides, and T trichiura, respectively. Egg reduction rates were above 88% for all three species. Rapid re-infection with A. lumbricoides was observed: the prevalence 4 and 6 months post-treatment was 75.8% and 83.8%, respectively. Re-infection with hookworm and T trichiura was considerably slower.