Elevated IgG anti-histone antibodies in a subgroup of medicated schizophrenic patients.
Elevated IgG anti-histone antibodies in a subgroup of medicated schizophrenic patients.
复制标题
接受药物治疗的精神分裂症患者亚组中 IgG 抗组蛋白抗体升高。
DOI：
10.1016/0920-9964(92)90073-e
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发表时间：
1992
影响因子：
4.5
通讯作者：
Ganguli,R
中科院分区：
文献类型：
--
作者：
Chengappa,KN;Carpenter,AB;Yang,ZW;Brar,JS;Rabin,BS;Ganguli,R
采用酶免疫测定法（ELISA）对57例精神分裂症患者（其中17例首发抗精神病药患者）和76例健康对照进行抗组蛋白IgG抗体筛选。所有患者抗组蛋白抗体滴度均显著高于对照组（t=3.1,p<0.003）。既往用药患者的滴度明显高于首次服用抗精神病药的患者（t=2.87,p<0.006）。本研究提示，抗组蛋白抗体与抗神经安定药物有关。
A total of 57 schizophrenic patients (of which 17 were first-episode, neuroleptic naive) and 76 healthy controls were screened for anti-histone IgG antibodies using an enzyme immunoassay (ELISA). All patients had significantly higher anti-histone antibody titers than controls (t=3.1,p<0.003). Previously medicated patients had significantly higher titers than neuroleptic-naive first episode patients (t=2.87,p<0.006). This study suggests that neuroleptic medications are associated with anti-histone antibodies.