Effects of citalopram on worry and brain activation in patients with generalized anxiety disorder
Effects of citalopram on worry and brain activation in patients with generalized anxiety disorder
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DOI：
10.1016/j.pscychresns.2004.02.003
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发表时间：
2004-05-30
影响因子：
2.3
通讯作者：
Wong, SHY
中科院分区：
文献类型：
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作者：
Hoehn-Saric, R;Schlund, MW;Wong, SHY
通过功能性磁共振成像测量，描述个人担忧的听觉陈述对大脑激活的影响在患有广泛性焦虑症（GAD）的患者中在使用西酞普兰减轻焦虑之前和之后进行了检查。六名患者在接受西酞普兰治疗前和治疗 7 周后，在听取个人担忧的口头描述或中性陈述时进行了成像。前后药物分析显示，西酞普兰治疗减少了自我报告的焦虑，并减少了对病理特异性担忧和中性刺激的大胆反应。治疗后，与中性陈述相比，担忧句子会引起前额叶区域、纹状体、岛叶和旁边缘区域的大胆反应减少。此外，治疗前后的对比显示，担忧和中性陈述之间存在的差异反应有所减少。在中性陈述期间，大胆反应的总体减少最为明显，尤其是在左半球。这些发现支持了临床印象，即广泛性焦虑症患者对病理特异性和非特异性线索反应过度，并且焦虑的减少会减弱对这两种类型线索的反应。 (C) 2004 Elsevier Ireland Ltd. 保留所有权利。
The effects of auditory statements describing a personal worry on brain activation as measured by functional magnetic resonance imaging were examined in patients with generalized anxiety disorder (GAD) before and after anxiety reduction with citalopram. Six patients were imaged while listening to verbal descriptions of a personal worry or a neutral statement before treatment with citalopram and after 7 weeks of treatment. Pre-post drug analyses showed treatment with citalopram reduced self-reported anxiety and reduced BOLD responses to a pathology-specific worry and a neutral stimulus. After treatment, worry sentences, compared to neutral statements, elicit reduced BOLD responses in prefrontal regions, the striatum, insula and paralimbic regions. In addition, contrasts before and after treatment revealed reductions in the differential response that existed between worry and neutral statements. Overall reduction of BOLD response was most prominent during neutral statements, particularly in the left hemisphere. These findings support the clinical impression that GAD patients overreact to both pathology-specific and non-specific cues and that the reduction of anxiety attenuates the response to both types of cues. (C) 2004 Elsevier Ireland Ltd. All rights reserved.