Psychosocial stress-induced activation of salivary alpha-amylase - An indicator of sympathetic activity?
Psychosocial stress-induced activation of salivary alpha-amylase - An indicator of sympathetic activity?
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DOI：
10.1196/annals.1314.033
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发表时间：
2004-01-01
期刊：
影响因子：
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通讯作者：
Kirschbaum, C
中科院分区：
文献类型：
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作者：
Rohleder, N;Nater, UM;Kirschbaum, C
交感肾上腺髓质系统（SAM）活性的评估只能通过测量血浆中的儿茶酚胺或通过电生理方法进行。这两种测量方法都局限于内分泌学或心理生理学实验室，因为它们都需要立即冷冻血液样本或使用复杂的记录设备。因此，人们一直在努力寻找一种与唾液皮质醇测量相媲美的方法，这种方法可以在任何地方采集非侵入性样本，并在室温下储存足够的时间，然后再在实验室进行分析。唾液α -淀粉酶（sAA）是一种可能在这种情况下证明有用的候选酶。我们在这里表明，sAA活性在急性社会心理压力（特里尔社会压力测试）下增加，sAA的增加与去甲肾上腺素的增加相关。我们进一步报道，sAA表现出一个稳定的昼夜节律模式，反映了唾液皮质醇。总之，目前的数据表明，唾液α -淀粉酶可以作为一种易于使用的SAM活性指标。然而，仍有一些问题有待解答；例如，唾液流速对应激诱导的sAA活性有何影响？
Assessment of sympathoadrenal medullary system (SAM) activity is only possible to date via measurement of catecholamines in blood plasma or via electrophysiological methods. Both ways of measurement are restricted to endocrinological or psychophysiological laboratories, as both require either immediate freezing of blood samples or complex recording devices. Efforts have therefore been undertaken to find a method comparable to salivary cortisol measurements, in which noninvasive samples can be taken at any place and stored at room temperature for sufficient time before later analysis in the laboratory. Salivary alpha-amylase (sAA) is a candidate that may prove useful in this context. We show here that sAA activity is increased by acute psychosocial stress (Trier Social Stress Test) and that increases in sAA correlate with increases in norepinephrine. We further report that sAA exhibits a stable circadian pattern that mirrors that of salivary cortisol. In conclusion, the current data show that salivary alpha-amylase may serve as an easy-to-use index for SAM activity. However, some questions remain to be answered; for example, what impact does salivary flow rate exert on stress-induced sAA activity?