Impact of imperfect Mycobacterium avium subsp paratuberculosis vaccines in dairy herds: A mathematical modeling approach
Impact of imperfect Mycobacterium avium subsp paratuberculosis vaccines in dairy herds: A mathematical modeling approach
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DOI：
10.1016/j.prevetmed.2012.08.001
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发表时间：
2013-02-01
影响因子：
2.6
通讯作者：
Groehn, Yrjoe T.
中科院分区：
文献类型：
--
作者：
Lu, Zhao;Schukken, Ynte H.;Groehn, Yrjoe T.
本研究的目的是调查不完善的鸟分枝杆菌亚种的潜在影响。副结核杆菌（MAP）疫苗对美国奶牛群中MAP感染动态的影响。已经实施了基于疫苗的控制计划，以减少一些奶牛群中MAP感染的患病率;然而，MAP疫苗是不完善的。疫苗可以为易感犊牛提供部分保护，降低MAP散毒动物的传染性，延长感染动物的潜伏期，减缓感染动物从低散毒到高散毒的进程，减少临床疾病。为了定量研究不完善的MAP疫苗的影响，我们开发了一个确定性的多组疫苗接种模型，并进行了全局敏感性分析。我们的研究结果解释了为什么MAP疫苗接种在降低患病率方面可能具有有益的、可忽略的或有害的影响，并表明对个体动物有益的疫苗可能对预防性控制计划没有用。该研究表明，旨在降低宿主易感性的高效疫苗在控制MAP传播方面最有效。这项工作表明，MAP疫苗接种应纳入一个全面的控制计划，包括测试和剔除干预和改善犊牛饲养管理。(c)2012爱思唯尔有限公司版权所有。
The objective of this study was to investigate the potential impacts of imperfect Mycobacterium avium subsp. paratuberculosis (MAP) vaccines on the dynamics of MAP infection in US dairy herds using a mathematical modeling approach. Vaccine-based control programs have been implemented to reduce the prevalence of MAP infection in some dairy herds; however, MAP vaccines are imperfect. Vaccines can provide partial protection for susceptible calves, reduce the infectiousness of animals shedding MAP, lengthen the latent period of infected animals, slow the progression from low shedding to high shedding in infectious animals, and reduce clinical disease. To quantitatively study the impacts of imperfect MAP vaccines, we developed a deterministic multi-group vaccination model and performed global sensitivity analyses. Our results explain why MAP vaccination might have a beneficial, negligible, or detrimental effect in the reduction of prevalence and show that vaccines that are beneficial to individual animals may not be useful for a herd-level control plan. The study suggests that high efficacy vaccines that are aimed at reducing the susceptibility of the host are the most effective in controlling MAP transmission. This work indicates that MAP vaccination should be integrated into a comprehensive control program that includes test-and-cull intervention and improved calf rearing management. (c) 2012 Elsevier B.V. All rights reserved.