Prognostic significance of S100A4 mRNA and protein expression in colorectal cancer
Prognostic significance of S100A4 mRNA and protein expression in colorectal cancer
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DOI：
10.1002/jso.22070
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发表时间：
2012-02-01
影响因子：
2.5
通讯作者：
Kang, Chang-Suk
中科院分区：
文献类型：
--
作者：
Kang, Yoon-Goo;Jung, Chan-Kwon;Kang, Chang-Suk
背景与目的钙结合蛋白S100 A4促进肿瘤的进展和转移。方法：采用免疫组化组织芯片技术检测526例结直肠癌组织中S100 A4蛋白的表达，并分析其临床病理意义。结果：S100 A4蛋白在包括肿瘤细胞在内的多种细胞中均有表达，而S100 A4 mRNA仅在肿瘤细胞中表达。S100 A4蛋白在526例肿瘤中有127例（24.1%）胞浆表达，并与年龄、浸润深度、淋巴结转移和总生存率相关。136例（25.9%）肿瘤中观察到S100 A4蛋白的核表达，并且与浸润深度、神经周围浸润和较差的总生存率显著相关。S100 A4 mRNA表达与临床病理参数无相关性。结论：S100 A4蛋白在结直肠癌中的表达可能提示肿瘤的进展和淋巴结转移，对预测结直肠癌患者的总生存期有一定的参考价值。《肿瘤外科杂志》2012; 105：119-124. (C)2011 Wiley Periodicals，Inc.
Background and Objectives The calcium-binding protein S100A4 promotes tumor progression and metastasis. We investigated the expression of S100A4 in colorectal cancer and its clinicopathologic significance in colorectal cancer.Methods: A total of 526 colorectal cancer patients were examined for S100A4 protein by immunohistochemistry using tissue microarrays. S100A4 mRNA was subsequently investigated by in situ hybridization.Results: S100A4 protein was expressed in various cell types including tumor cells, but S100A4 mRNA was only expressed in tumor cells. Cytoplasmic expression of S100A4 protein was seen in 127 (24.1%) of 526 tumors and significantly correlated with older age, depth of invasion, lymph node metastasis, and worse overall survival. Nuclear expression of S100A4 protein was observed in 136 (25.9%) tumors and significantly related to the depth of invasion, perineural invasion, and worse overall survival. However, there was no correlation between S100A4 mRNA expression and clinicopathological parameters. Upon multivariate analysis nuclear expression of S100A4 protein was found to be an independent prognostic factor of poor survival.Conclusions: Expression of S100A4 protein in colorectal cancers may indicate tumor progression and lymph node metastasis and can be useful for prediction of overall survival of patients with colorectal cancers. J. Surg. Oncol. 2012; 105: 119-124. (C) 2011 Wiley Periodicals, Inc.