Control of meiosis by respiration
Control of meiosis by respiration
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DOI：
10.1016/j.cub.2008.05.047
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发表时间：
2008-07-08
期刊：
影响因子：
9.2
通讯作者：
Amon, Angelika
中科院分区：
文献类型：
--
作者：
Jambhekar, Ashwini;Amon, Angelika
细胞进行减数分裂的决定是由多种信号调节的。在芽殖酵母中，这些信号包括交配型状态、营养饥饿和呼吸;呼吸的需要通常表现为对不可发酵碳源的需求。我们已经剖析了呼吸作用和碳源在促进进入减数分裂程序中的作用。这一分析表明，呼吸是需要整个减数分裂，但nonfermentable碳源是必要的，只有在减数分裂核分裂。在减数分裂的早期阶段，不可发酵的碳源起着几种作用。它是Polll转录、DNA复制和重组所必需的。最后，虽然在nonrespiring细胞的转录和缺乏DNA复制的全球下调可能是由于缺乏能量，我们表明，不能诱导基因启动进入减数分裂程序不是。我们建议，一个单独的呼吸感应途径支配减数分裂进入。
A cell's decision to undergo meiosis is regulated by multiple signals. In budding yeast, these signals include mating-type status, nutrient starvation, and respiration; the need for respiration is often manifested as a requirement for a nonfermentable carbon source. We have dissected the roles of respiration and carbon source in promoting entry into the meiotic program. This analysis revealed that respiration is needed throughout meiosis but a nonfermentable carbon source is necessary only prior to the meiotic nuclear divisions. A nonfermentable carbon source serves several roles during the early stages of meiosis. It is required for Polll transcription, DNA replication, and recombination. Finally, although the global downregulation of transcription and lack of DNA replication in nonrespiring cells could be due to a lack of energy, we show that the inability to induce genes initiating entry into the meiotic program is not. We propose that a separate respiration-sensing pathway governs meiotic entry.