PULMONARY FUNCTION IN NEWBORN INFANT - ALVEOLAR-ARTERIAL OXYGEN GRADIENT
PULMONARY FUNCTION IN NEWBORN INFANT - ALVEOLAR-ARTERIAL OXYGEN GRADIENT
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DOI：
10.1152/jappl.1963.18.3.534
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发表时间：
1963-01-01
影响因子：
3.3
通讯作者：
CHERRY, RB
中科院分区：
文献类型：
--
作者：
NELSON, NM;PRODHOM, LS;CHERRY, RB
The venous admixture component of the total alveolar-arterial gradient for oxygen (AaD-02) has been measured in 26 normal infants less than 4 days of age and in 12 others with the respiratory distress syndrome (hyaline membrane disease). The AaD-02 in normal air-breathing infants (average 28 mm Hg) is nearly three times that seen in adults. Analysis of mixing data from N2-washout curves in these infants suggests such excellent distribution of ventilation that the distribution component of the AaD-O2 must be quite small. By contrast, estimates of the shunt component during oxygen breathing reveal a shunt flow in normal infants of nearly one-fourth cardiac output (AaD-O2 = 311) which is further increased in distressed babies (up to two-thirds cardiac output) and which can completely account for the large AaD-02''s found in both groups of infants.
