Alzheimer's Disease: Mechanism and Approach to Cell Therapy.
Alzheimer's Disease: Mechanism and Approach to Cell Therapy.
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DOI：
10.3390/ijms161125961
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发表时间：
2015-11-04
影响因子：
5.6
通讯作者：
Sykova E
中科院分区：
文献类型：
--
作者：
Amemori T;Jendelova P;Ruzicka J;Urdzikova LM;Sykova E
阿尔茨海默病（AD）是痴呆症最常见的形式。AD的风险随着年龄的增长而增加。尽管Alois Alzheimer在世纪就已经认识到AD的两个主要病理特征，即淀粉样斑块和神经纤维缠结，但其发病机制至今仍不清楚。靶向斑块或缠结的治疗方法尚未导致AD治疗的令人满意的改善。这可能部分是由于早发性和迟发性AD的发病机制不同。大多数AD动物模型是由早发性家族性AD的基因突变产生的，仅占所有病例的1%，这可能使我们对AD机制的理解变得复杂。在本文中，作者根据两种主要的神经病理学讨论了AD的发病机制，包括衰老相关机制以及使用干细胞（即间充质干细胞和神经干细胞）的可能治疗方法。
Alzheimer’s disease (AD) is the most common form of dementia. The risk of AD increases with age. Although two of the main pathological features of AD, amyloid plaques and neurofibrillary tangles, were already recognized by Alois Alzheimer at the beginning of the 20th century, the pathogenesis of the disease remains unsettled. Therapeutic approaches targeting plaques or tangles have not yet resulted in satisfactory improvements in AD treatment. This may, in part, be due to early-onset and late-onset AD pathogenesis being underpinned by different mechanisms. Most animal models of AD are generated from gene mutations involved in early onset familial AD, accounting for only 1% of all cases, which may consequently complicate our understanding of AD mechanisms. In this article, the authors discuss the pathogenesis of AD according to the two main neuropathologies, including senescence-related mechanisms and possible treatments using stem cells, namely mesenchymal and neural stem cells.