Ischemic stroke: Relation of age, lesion location, and initial neurologic deficit to functional outcome
Ischemic stroke: Relation of age, lesion location, and initial neurologic deficit to functional outcome
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DOI：
10.1016/s0003-9993(98)90271-4
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发表时间：
1998-10-01
影响因子：
4.3
通讯作者：
Mertz, T
中科院分区：
文献类型：
--
作者：
Macciocchi, SN;Diamond, PT;Mertz, T
目的：建立年龄、性别、初始神经功能缺失、卒中部位、既往卒中史、卒中半球与缺血性卒中患者功能结局之间的关系。设计：单组、多因素、重复测量设计，纳入来自20个参与中心的327名缺血性卒中患者。患者：连续入院的男性和女性，年龄在40岁到85岁之间，由大脑中动脉缺血引起的大脑半球中风，统一的神经中风评分在5到24分之间。干预：纳入试验的住院患者接受了包括物理治疗、作业治疗和适当的语言治疗在内的传统康复治疗。主要观察指标：在中风后7-10天和3个月时计算Barthel指数。结果：积极的功能结果与既往没有中风病史、年龄更小、初始神经功能障碍较轻、卒中累及皮质结构和优势(左半球)病变有关。结论：尽管现有文献中存在一些不一致的情况，但仍可获得良好的功能结果对卒中后预后的标准化前瞻性检查清楚地显示了年龄、卒中初始严重程度和病变部位作为功能预后预测因子的作用。(C)1998年由美国康复医学大会和美国物理医学和康复学会主办。
Objective: Establish the relation between age, gender, initial neurologic deficit, stroke location, prior stroke, hemisphere of stroke, and functional outcome in ischemic stroke.Design: Single group, multivariate, repeated measures design with 327 persons having ischemic stroke recruited from 20 participating centers.Setting: Twenty European stroke centers. Patients: Consecutive admissions of men and women between the ages of 40 and 85yrs with a hemispheric stroke caused by middle cerebral artery ischemia and a Unified Neurological Stroke Scale score of 5 to 24.Interventions: Inpatients enrolled in the trial received traditional rehabilitation therapies including physical therapy, occupational therapy, and speech therapy when appropriate.Main Outcome Measures: Barthel Index computed at 7 to 10 days and 3 months poststroke.Results: Positive functional outcomes were significantly related to the absence of prior strokes, a younger age, a less severe initial neurologic deficit, stroke involving cortical structures, and dominant (left hemisphere) lesions.Conclusions: Despite some inconsistencies in existing literature, standardized prospective examination of outcome after stroke clearly demonstrated the effect of age, initial severity of stroke, and lesion location as predictors of functional outcome. (C) 1998 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation.