Maternal Antiasthma Simplified Herbal Medicine Intervention therapy prevents airway inflammation and modulates pulmonary innate immune responses in young offspring mice.
Maternal Antiasthma Simplified Herbal Medicine Intervention therapy prevents airway inflammation and modulates pulmonary innate immune responses in young offspring mice.
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母体平喘简化草药干预疗法可预防幼代小鼠的气道炎症并调节肺部先天免疫反应。
DOI：
10.1016/j.anai.2014.10.018
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Li,Xiu-Min
中科院分区：
文献类型：
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作者：
López-Expósito,Iván;Srivastava,KamalD;Birmingham,Neil;Castillo,Alexandra;Miller,RachelL;Li,Xiu-Min
过敏性哮喘是一种起源于生命早期的疾病1，几项研究表明过敏性致敏可发生在产前发育期间。2-4父母有哮喘病史，5特别是母亲有哮喘病史，6会增加儿童发生哮喘的风险（OR= 5.0，95% CI= 1.7 - 14.9），母亲的过敏性气道疾病（如过敏性鼻炎）也与儿童哮喘的发生有关。7-10母体对后代哮喘易感性的影响一直是许多动物模型研究的焦点。这些研究在很大程度上探讨了后代对致敏的易感性问题，使用的方案在抗原剂量或时间上各不相同，但总是包括攻毒前的致敏期。Hamada等11使用这些方法证明，卵蛋白诱导的“慢性哮喘”小鼠的后代在一个次优方案后更容易患哮喘，该方案包括在出生后4天腹腔注射一次佐剂中的过敏原，然后在出生后12-14天连续3次用雾化过敏原激发。同样地，Fedulov等人表明，即使卵蛋白哮喘小鼠的后代在6周龄时开始致敏，它们也会发展出完全的哮喘表型。Royer等人也开发了一种使用犬的类似模型12，其中豚草（RW）致敏但不正常的雌性犬的后代在接种后出现哮喘样特征。
Allergic asthma is a disease with origins in early life1, with several studies indicating allergic sensitization can occur during prenatal development. 2–4 Having a parental history of asthma, 5 specifically maternal asthma, 6 increases the risk that a child will develop asthma (OR= 5.0, 95% CI= 1.7 to 14.9), and maternal allergic airway diseases such as allergic rhinitis are also associated with asthma development in children. 7–10 Maternal effect on asthma susceptibility in offspring has been a focus of several animal model studies. These studies have largely explored the question of offspring susceptibility to sensitization using protocols that vary in antigen dose or timing but always include a period of sensitization prior to challenge. Using such methods, Hamada et al11 demonstrated that offspring of mice with OVA-induced “chronic asthma” were more susceptible to asthma after a suboptimal protocol consisting of one intraperitoneal injection of allergen in adjuvant at 4 days of life, followed by 3 consecutive challenges with aerosolized allergen on days 12–14 of life. Likewise, Fedulov et al showed that offspring of OVA-asthmatic mice develop a full asthma phenotype even if they are initially sensitized as late as 6 weeks of age. A similar model using canines has also been developed by Royer et al12 where offspring from ragweed (RW)-sensitized, but not normal, female dogs developed asthma-like features upon post