Serum Antibody to Porphyromonas gingivalis in Chronic Kidney Disease
Serum Antibody to Porphyromonas gingivalis in Chronic Kidney Disease
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DOI：
10.1177/0022034512455063
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发表时间：
2012-09-01
影响因子：
7.6
通讯作者：
Miyazaki, H.
中科院分区：
文献类型：
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作者：
Iwasaki, M.;Taylor, G. W.;Miyazaki, H.
最近的研究报告了牙周病和慢性肾脏病（CKD）之间潜在的显着关联。这项横断面研究的目的是调查 215 名 79 岁日本人的牙周病原体牙龈卟啉单胞菌 (P. gingivalis) 血清抗体与 CKD 之间的关联。通过酶联免疫吸附测定法测量针对牙龈卟啉单胞菌的血清抗体水平。升高的血清抗体反应被定义为上四分位数，并与下三个四分位数进行比较。当参与者的肾小球滤过率在 15 至 59 mL/min/1.73 m(2) 之间时，他们被归类为患有 CKD。使用多变量逻辑回归模型来评估抗体状态升高与 CKD 存在之间的关联。血清牙龈卟啉单胞菌抗体升高的研究参与者患 CKD 的可能性高出 2.6 倍。同时调整其他协变量后，与较低四分位数的其他参与者相比，牙龈卟啉单胞菌血清抗体最高四分位数的参与者的 CKD 调整后比值比为 2.59（95% 置信区间，1.05-6.34）。总之，本研究表明，在社区日本老年人群中，牙龈卟啉单胞菌血清抗体升高与肾功能下降显着相关。
Potentially significant associations between periodontal disease and chronic kidney disease (CKD) have been reported in recent studies. The aim of this cross-sectional study was to investigate the association between serum antibody to the periodontal pathogen Porphyromonas gingivalis (P. gingivalis) and CKD in 215 Japanese individuals, aged 79 yrs. Serum antibody levels to P. gingivalis were measured by enzyme-linked immunosorbent assay. An elevated serum antibody response was defined as the upper quartile and was compared with the bottom three quartiles. Participants were classified as having CKD when their glomerular filtration rate was between 15 and 59 mL/min/1.73 m(2). A multivariable logistic regression model was used to evaluate the association between elevated antibody status and the presence of CKD. Study participants with an elevated serum antibody to P. gingivalis were 2.6 times more likely to have CKD. The adjusted odds ratio of CKD for participants in the highest quartile of serum antibody to P. gingivalis was 2.59 (95% confidence interval, 1.05-6.34) when compared with others in lower quartiles after simultaneous adjustment for other covariates. In conclusion, the present study suggests that elevated serum antibody to P. gingivalis was significantly associated with decreased kidney function in a community-based cohort of elderly Japanese.