Amygdala reactivity is inversely related to level of cannabis use in individuals with comorbid cannabis dependence and major depression
Amygdala reactivity is inversely related to level of cannabis use in individuals with comorbid cannabis dependence and major depression
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DOI：
10.1016/j.addbeh.2010.02.004
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发表时间：
2010-06-01
影响因子：
4.4
通讯作者：
Hariri, Ahmad R.
中科院分区：
文献类型：
--
作者：
Cornelius, Jack R.;Aizenstein, Howard J.;Hariri, Ahmad R.
Phan等人（2008年）最近报告说，在社会威胁刺激任务期间，急性剂量的口服THC与威胁相关的杏仁核反应性降低有关。然而，到目前为止，这些研究结果尚未得到复制，也没有扩展到涉及吸烟而不是口服大麻的临床研究。在这项研究中，我们假设在我们的治疗研究中，参与者吸食大麻的水平与威胁相关的杏仁核反应水平呈负相关。受试者是从我们的双盲、安慰剂对照试验中招募的，该试验在患有大麻依赖/重度抑郁症的共病青年中进行。Hariri et al.（2009）使用的威胁相关杏仁核反应任务在研究基线时的BOLD fMRI扫描期间完成，然后在12周后试验结束时再次完成。数据可从6名受试者治疗前和治疗后的fMRI数据。在研究过程中，六名受试者中有五名表现出大麻使用水平下降，平均下降64%，这些人都表现出杏仁核反应水平的增加。一名受试者在治疗试验期间表现出大麻使用水平的增加（增加了79%），并且该人表现出杏仁核反应水平的降低。因此，在所有受试者中，较高水平的大麻使用始终与较低水平的杏仁核反应性相关（配对t = 2.70，df = 5，p
Phan et al. (2008) recently reported that an acute dose of oral THC is associated with a decrease in threat-related amygdala reactivity during a social threat stimulus task. However, to date, those findings have not been replicated, and have not been extended to clinical studies involving smoked rather than oral cannabis. In this study, we hypothesized that level of cannabis smoked by participants in our treatment study would be inversely related to the level of threat-related amygdala reactivity. Subjects were recruited from among participants in our double-blind, placebo-controlled trial of fluoxetine in comorbid youth with cannabis dependence/major depression. The threat-related amygdala reactivity task used by Hariri et al. (2009) was completed during BOLD fMRI scans at study baseline and then again 12 weeks later at the end of the trial. Data are available from six subjects with pre-and post-treatment fMRI data. During the course of the study, five of the six subjects demonstrated a decrease in their level of cannabis use, with a mean decrease of 64%, and those persons all demonstrated an increase in their level of amygdala reactivity. One subject demonstrated an increase in their level of cannabis use (a 79% increase) during the treatment trial, and that person demonstrated a decrease in their level of amygdala reactivity. Thus, a higher level of cannabis use was consistently associated with a lower level of amygdala reactivity across all subjects (matched pairs t = 2.70, df = 5, p