Nrf2-Mediated Metabolic Reprogramming in Cancer.

Nrf2-Mediated Metabolic Reprogramming in Cancer.
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Nrf2 介导的癌症代谢重编程

DOI:
10.1155/2018/9304091
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发表时间:
2018
影响因子:
--
通讯作者:
Zhe H
Zhe H
中科院分区:
生物学2区
文献类型:
--
作者:
Wang YY;Chen J;Liu XM;Zhao R;Zhe H

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代谢重编程是癌症的标志之一。 Nrf2 通路是细胞防御和抵抗氧化应激的关键信号级联反应之一。 Nrf2 在癌症代谢中的重要性开始得到认识。在这篇小综述中,我们重点关注 Nrf2 介导的癌症代谢重编程,并打算强调 Nrf2 在通过代谢适应调节恶性转化、癌症增殖和治疗耐药性发展中的作用。我们希望在不久的将来开发出基于 Nrf2 引导的癌症代谢重编程的非侵入性生物标志物和新的癌症治疗方法。
Metabolic reprogramming is one of the hallmarks of cancer. Nrf2 pathway is one of the critical signaling cascades involved in cell defense and survival against oxidative stress. The significance of Nrf2 in cancer metabolism begins to be recognized. In this minireview, we focus on the Nrf2-mediated cancer metabolic reprogramming and intend to highlight the role of Nrf2 in the regulation of malignant transformation, cancer proliferation, and the development of treatment resistance via metabolic adaptations. We hope for the development of noninvasive biomarkers and novel therapeutic approaches for cancer based on Nrf2-directed cancer metabolic reprogramming in the near future.
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