Spatial wettability patterning of glass microchips for water-in-oil-in-water (W/O/W) double emulsion preparation
Spatial wettability patterning of glass microchips for water-in-oil-in-water (W/O/W) double emulsion preparation
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DOI：
10.1016/j.snb.2015.03.072
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发表时间：
2015-08-01
影响因子：
8.4
通讯作者：
Wang, Min
中科院分区：
文献类型：
--
作者：
Bai, Zeqing;Wang, Bo;Wang, Min
双重乳剂在化妆品、食品和药物输送等领域具有巨大的应用潜力。然而，目前双乳液的制备方法不能很好地控制乳液的大小和结构。微流控技术为这一领域开辟了新的机遇，但挑战依然存在。本文介绍了一种用于生成油包水（W/O/W）双乳液的部分亲水性和部分疏水性玻璃微芯片。该器件首先通过在整个微通道表面自组装形成十八烷基三氯硅烷层来疏水。然后，利用深紫外光源和掩膜对疏水有机层进行空间光降解，得到亲水表面。因此，在微通道表面的不同部分实现了独特的润湿性对比。通过优化紫外照射时间，在微芯片上成功制备了W/O/W双乳液。该装置制备的双乳具有单分散、粒径分布窄、变异系数小于8%的特点。此外，通过调节流速可以控制内部液滴的大小和数量。(C) 2015 Elsevier B.V.版权所有
Double emulsions are of great potential in many applications, including cosmetics, foods, and drug delivery. However, current preparation methods for double emulsions are not able to satisfactorily control emulsion size and structure. Microfluidic techniques open up new opportunities for this field but challenges still remain. This article presents a partially hydrophilic and partially hydrophobic glass microchip for generating water-in-oil-in-water (W/O/W) double emulsions. The device was first hydrophobized by forming an octadecyltrichlorosilane layer through self-assembly on the entire microchannel surface. Then, a hydrophilic surface was obtained by spatially photodegrading the hydrophobic organic layer with a deep UV-light source and a photomask. Thus, a distinctive wettability contrast was achieved on different parts of the microchannel surface. By optimizing the UV irradiation time, W/O/W double emulsions were successfully created on the microchip. Double emulsions prepared by this device were monodisperse and had narrow size distribution with coefficient of variation values less than 8%. Moreover, both the size and the number of inner droplets could be controlled by adjusting the flow rates. (C) 2015 Elsevier B.V. All rights reserved.