Role of Retrosplenial Cortex in Processing Stress-Related Context Memories
Role of Retrosplenial Cortex in Processing Stress-Related Context Memories
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DOI：
10.1037/bne0000223
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发表时间：
2018-10-01
影响因子：
1.9
通讯作者：
Radulovic, Jelena
中科院分区：
文献类型：
--
作者：
Corcoran, Kevin A.;Yamawaki, Naoki;Radulovic, Jelena
这项工作总结了RSC在处理恐惧诱导的背景记忆中的作用的证据。具体来说，我们讨论了分子，细胞和网络机制，RSC可能有助于上下文恐惧记忆的处理。我们专注于潜在的编码，检索和灭绝的情境依赖性恐惧的多巴胺能和胆碱能机制。RSC机制检索最近和远程获得的记忆相比，前皮质的记忆机制。由于海马和RSC之间的强连接性，我们还比较了它们的编码，检索和灭绝机制的重叠程度。在理论层面上，我们讨论了RSC在系统巩固以及检索诱导的记忆调制的框架中的作用。最后，我们强调这些发现对与神经和精神疾病相关的精神病理学的影响。
This work summarizes evidence for the role of RSC in processing fear-inducing context memories. Specifically, we discuss molecular, cellular, and network mechanisms by which RSC might contribute the processing of contextual fear memories. We focus on glutamatergic and cholinergic mechanisms underlying encoding, retrieval, and extinction of context-dependent fear. RSC mechanisms underlying retrieval of recently and remotely acquired memories are compared to memory mechanisms of anterior cortices. Due to the strong connectivity between hippocampus and RSC, we also compare the extent to which their mechanisms of encoding, retrieval, and extinction show overlap. At a theoretical level, we discuss the role of RSC in the framework of systems consolidation as well as retrieval-induced memory modulation. Lastly, we emphasize the implication of these findings for psychopathologies associated with neurological and psychiatric disorders.