Carbon Dots Fabrication: Ocular Imaging and Therapeutic Potential.
Carbon Dots Fabrication: Ocular Imaging and Therapeutic Potential.
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DOI：
10.3389/fbioe.2020.573407
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发表时间：
2020
影响因子：
5.7
通讯作者：
Biswal MR
中科院分区：
文献类型：
--
作者：
Garner I;Vichare R;Paulson R;Appavu R;Panguluri SK;Tzekov R;Sahiner N;Ayyala R;Biswal MR
视力丧失是常见眼部感染和细菌性角膜炎、年龄相关性黄斑变性（AMD）和糖尿病视网膜病变（DR）等疾病的主要并发症。此类眼科疾病的流行代表了开发安全、有效和长期治疗的迫切需要。目前的治疗方法充满了缺点和局限性，这需要探索替代的药物递送机制。用于药物递送的无机金属和金属氧化物的毒性引起了安全性问题，其通过交替使用生物相容性和环境友好的天然和有机聚合物而得到缓解。碳量子点（CD）由于其可调谐的荧光，生物相容性和与各种治疗材料结合的能力，在新的生物医学应用中代表了巨大的潜力。有越来越多的兴趣开发这些属性的药物输送与增强的生物成像。然而，CD应用于眼科适应症的报告有限。本文就CD治疗眼科疾病的潜力和转化治疗的发展作一综述。目前的审查提出了更好的理解制造的CD和它如何可能是有用的，在提供抗菌剂，抗VEGF分子，以及成像眼科应用。
Vision loss is a major complication in common ocular infections and diseases such as bacterial keratitis, age-related macular degeneration (AMD) and diabetic retinopathy (DR). The prevalence of such ophthalmic diseases represents an urgent need to develop safe, effective, and long-term treatments. Current therapies are riddled with drawbacks and limitations which calls for the exploration of alternative drug delivery mechanisms. Toxicity of the inorganic metals and metal oxides used for drug delivery raise safety concerns that are alleviated with the alternate use of, a natural and organic polymer which is both biocompatible and environmentally friendly. Carbon dots (CDs) represent a great potential in novel biomedical applications due to their tunable fluorescence, biocompatibility, and ability to be conjugated with diverse therapeutic materials. There is a growing interest on the exploitation of these properties for drug delivery with enhanced bio-imaging. However, there are limited reports of CD applications for ophthalmic indications. In this review, we focus on the CD potential and the development of translational therapies for ophthalmic diseases. The current review presents better understanding of fabrication of CDs and how it may be useful in delivering anti-bacterial agents, anti-VEGF molecules as well as imaging for ophthalmic applications.