Specialized Representations of Value in the Orbital and Ventrolateral Prefrontal Cortex: Desirability versus Availability of Outcomes.
Specialized Representations of Value in the Orbital and Ventrolateral Prefrontal Cortex: Desirability versus Availability of Outcomes.
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眼眶和腹外侧前额叶皮层价值的专门表示：结果的可取性与可用性。
DOI：
10.1016/j.neuron.2017.07.042
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发表时间：
2017
期刊：
影响因子：
16.2
通讯作者：
Murray,ElisabethA
中科院分区：
文献类型：
--
作者：
Rudebeck,PeterH;Saunders,RichardC;Lundgren,DawnA;Murray,ElisabethA
有利的觅食选择得益于对资源价值的两个方面的估计：当前的可取性和可用性。眼眶前额区和腹外侧额前区都有助于更新这些估值，但它们的确切作用尚不清楚。为了探索它们的专业性，我们对猕猴进行了两项任务的训练：一项要求更新预测结果的可取性表示，根据选择性饱足感进行调整；另一项要求更新结果可用性的表示，根据其概率进行索引。我们评估了三组猴子在这两个任务上的表现：未手术的对照组和那些选择性地、纤维保留的OFC或VLPFC病变的猴子。依赖于VLPFC但不依赖于OFC的陈述在基于结果可获得性的选择中发挥了必要的作用；相反，依赖于OFC但不依赖于VLPFC的陈述在基于结果合意性的选择中扮演了必要的角色。
Advantageous foraging choices benefit from an estimation of two aspects of a resource's value: its current desirability and availability. Both orbitofrontal and ventrolateral prefrontal areas contribute to updating these valuations, but their precise roles remain unclear. To explore their specializations, we trained macaque monkeys on two tasks: one required updating representations of a predicted outcome's desirability, as adjusted by selective satiation, and the other required updating representations of an outcome's availability, as indexed by its probability. We evaluated performance on both tasks in three groups of monkeys: unoperated controls and those with selective, fiber-sparing lesions of either the OFC or VLPFC. Representations that depend on the VLPFC but not the OFC play a necessary role in choices based on outcome availability; in contrast, representations that depend on the OFC but not the VLPFC play a necessary role in choices based on outcome desirability.