Fibrinogen and factor VIII, but not factor VII, are associated with measures of subclinical cardiovascular disease in the elderly. Results from The Cardiovascular Health Study.
Fibrinogen and factor VIII, but not factor VII, are associated with measures of subclinical cardiovascular disease in the elderly. Results from The Cardiovascular Health Study.
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纤维蛋白原和因子 VIII（而非因子 VII）与老年人亚临床心血管疾病的测量相关。
DOI：
10.1161/01.atv.15.9.1269
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Savage,PJ
中科院分区：
文献类型：
--
作者：
Tracy,RP;Bovill,EG;Yanez,D;Psaty,BM;Fried,LP;Heiss,G;Lee,M;Polak,JF;Savage,PJ
没有研究检查凝血因子水平与老年人亚临床心血管疾病（CVD）的相关性。心血管健康研究（CHS）是一项在65岁以上人群中进行的前瞻性、基于人群的CVD队列研究。在基线检查时，我们测量了5201名CHS参与者中的5024名的纤维蛋白原、因子VII和因子VIII水平，并在横断面分析中检查了这些凝血因子与亚临床CVD指标的相关性。亚临床CVD测量基于心电图、颈动脉超声、超声心动图和踝臂血压测量（AAI）。为了进行分析，我们使用了整个队列以及两个相互排斥的亚组：基线时有普遍临床CVD的患者和无临床CVD的患者。纤维蛋白原和较小程度的因子VIII与各种亚临床CVD指标呈正相关。在年龄调整分析中，纤维蛋白原和因子VIII与10项指标中的8项显著相关。在多变量分析中，纤维蛋白原与颈动脉狭窄、颈内动脉（但不常见）壁厚和AAI显著相关。仅在整个队列中，因子VIII与室壁运动异常和AAI相关。因子VII与亚临床疾病指标并不一致。在包括所有三组数据的双变量分析中，因子VII有5个阳性亚临床疾病关联和5个阴性关联。在多变量分析中，在整个队列或任一亚组中，因子VII和亚临床CVD之间没有显著相关性。我们的结论是，在这些横断面分析中，纤维蛋白原和在较小程度上因子VIII与亚临床CVD在老年人，即使在那些没有症状或临床CVD的历史。然而，因子VII与老年人亚临床CVD无关。
No studies have examined the associations of coagulation factor levels with measures of subclinical cardiovascular disease (CVD) in the elderly. The Cardiovascular Health Study (CHS) is a prospective, population-based cohort study of CVD in persons older than 65 years. At the baseline examination, we measured fibrinogen, factor VII, and factor VIII levels in 5024 of the 5201 participants of the CHS and examined the associations of these coagulation factors with measures of subclinical CVD in a cross-sectional analysis. Subclinical CVD measures were based on electrocardiography, carotid ultrasonography, echocardiography, and ankle-arm blood pressure measurements (AAI). For analyses, we used the full cohort as well as two mutually exclusive subgroups: those with prevalent clinical CVD at baseline and those without. Fibrinogen and to a lesser extent factor VIII showed positive associations with a variety of subclinical CVD measures. In age-adjusted analyses, fibrinogen and factor VIII were significantly associated with 8 of 10 measures. In multivariate analyses, fibrinogen was significantly associated with carotid artery stenosis, internal (but not common) carotid artery wall thickness, and AAI. Factor VIII was associated with abnormal wall motion and AAI in the full cohort only. Factor VII was not consistently associated with subclinical disease measures. In bivariate analyses that included data from all three groups, there were 5 positive subclinical disease associations and 5 negative associations for factor VII. In multivariate analyses, there were no significant associations between factor VII and subclinical CVD in the full cohort or in either subgroup. We conclude that in these cross-sectional analyses, fibrinogen and to a lesser extent factor VIII are associated with subclinical CVD in the elderly, even in those without symptoms or a history of clinical CVD. Factor VII, however, was not associated with subclinical CVD in the elderly.