A proposed scoring system for assessing the severity of actinic keratosis on the head: actinic keratosis area and severity index
A proposed scoring system for assessing the severity of actinic keratosis on the head: actinic keratosis area and severity index
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DOI：
10.1111/jdv.14267
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发表时间：
2017-08-01
影响因子：
9.2
通讯作者：
Gupta, G.
中科院分区：
文献类型：
--
作者：
Dirschka, T.;Pellacani, G.;Gupta, G.
BackgroundActinic keratosis（AK）的严重程度是目前评价的主观评估patients.ObjectivesTo开发和执行一个新的易于使用的定量工具，用于评估AK严重程度的head.MethodsThe光化性角化病面积和严重程度指数（AKASI）的头部进行初步试点验证的基础上，审查其他严重程度评分系统在皮肤科，特别是银屑病面积和严重程度指数（PASI）。由13名医生使用医生总体评估（PGA）和AKASI评估18名AK患者和2名对照的AK严重程度进行初始验证。为了确定AKASI评分，将头部分为四个区域（头皮、前额、左/右脸颊、耳朵、下巴和鼻子）。在每个地区，受AKS影响的面积的百分比进行了估计，和AK的三个临床体征的严重程度进行了评估：分布，红斑和thickness.ResultsThere是AKASI和PGA评分之间的强相关性（皮尔逊相关系数：0.86）。AKASI能够区分不同的PGA类别：平均（SD）AKASI从轻度“的2.88（1.18）增加到中度”的5.33（1.48），重度“的8.28（1.89）和极重度”PGA分类的8.73（3.03）。AKASI分数的变异系数是低的，相对恒定的所有PGA categorization.ConclusionsActinic角化病的面积和严重程度指数提出了作为一个新的定量工具，用于评估AK的严重程度在头部。它可能是有用的，在未来的评估新的AK治疗的临床研究和管理AK在日常实践中。
BackgroundActinic keratosis (AK) severity is currently evaluated by subjective assessment of patients.ObjectivesTo develop and perform an initial pilot validation of a new easy-to-use quantitative tool for assessing AK severity on the head.MethodsThe actinic keratosis area and severity index (AKASI) for the head was developed based on a review of other severity scoring systems in dermatology, in particular the psoriasis area and severity index (PASI). Initial validation was performed by 13 physicians assessing AK severity in 18 AK patients and two controls using a physician global assessment (PGA) and AKASI. To determine an AKASI score, the head was divided into four regions (scalp, forehead, left/right cheek ear, chin and nose). In each region, the percentage of the area affected by AKs was estimated, and the severities of three clinical signs of AK were assessed: distribution, erythema and thickness.ResultsThere was a strong correlation between AKASI and PGA scores (Pearson correlation coefficient: 0.86). AKASI was able to discriminate between different PGA categories: mean (SD) AKASI increased from 2.88 (1.18) for light' to 5.33 (1.48) for moderate', 8.28 (1.89) for severe', and 8.73 (3.03) for very severe' PGA classification. The coefficient of variation for AKASI scores was low and relatively constant across all PGA categories.ConclusionsActinic keratosis area and severity index is proposed as a new quantitative tool for assessing AK severity on the head. It may be useful in the future evaluation of new AK treatments in clinical studies and the management of AK in daily practice.