Molecular Virology of KSHV in the Lymphocyte Compartment-Insights From Patient Samples and De Novo Infection Models.
Molecular Virology of KSHV in the Lymphocyte Compartment-Insights From Patient Samples and De Novo Infection Models.
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来自患者样品和从头感染模型的淋巴细胞室内室内室中KSHV的分子病毒学。
DOI：
10.3389/fcimb.2020.607663
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发表时间：
2020
影响因子：
5.7
通讯作者：
Totonchy J
中科院分区：
文献类型：
--
作者：
Aalam F;Totonchy J
卡波西肉瘤相关疱疹病毒（KSHV）相关卡波西肉瘤的发病率在目前有效的艾滋病毒治疗时代急剧下降。然而，KSHV相关的淋巴组织增生性疾病虽然罕见，但没有看到类似的下降。淋巴瘤现在是艾滋病毒感染者（PLWH）死亡的主要原因，这表明抗逆转录病毒疗法提供的免疫重建不足以完全纠正艾滋病毒感染造成的淋巴瘤免疫失调。因此，迫切需要对KSHV介导的免疫室发病机制的新见解，以开发旨在预防和治疗KSHV相关淋巴细胞增生的新疗法。在这篇综述中，我们将讨论我们目前的理解KSHV分子病毒学在淋巴细胞室，集中在研究探索独特的机制感染B淋巴细胞。
The incidence of Kaposi’s sarcoma-associated herpesvirus (KSHV)-associated Kaposi Sarcoma has declined precipitously in the present era of effective HIV treatment. However, KSHV-associated lymphoproliferative disorders although rare, have not seen a similar decline. Lymphoma is now a leading cause of death in people living with HIV (PLWH), indicating that the immune reconstitution provided by antiretroviral therapy is not sufficient to fully correct the lymphomagenic immune dysregulation perpetrated by HIV infection. As such, novel insights into the mechanisms of KSHV-mediated pathogenesis in the immune compartment are urgently needed in order to develop novel therapeutics aimed at prevention and treatment of KSHV-associated lymphoproliferations. In this review, we will discuss our current understanding of KSHV molecular virology in the lymphocyte compartment, concentrating on studies which explore mechanisms unique to infection in B lymphocytes.