Ventral striatum links motivational and motor networks during operant-conditioned movement in rats
Ventral striatum links motivational and motor networks during operant-conditioned movement in rats
复制标题
大鼠操作性条件运动期间，腹侧纹状体连接动机和运动网络
DOI：
10.1016/j.neuroimage.2018.10.018
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发表时间：
2019
期刊：
影响因子：
5.7
通讯作者：
Hanakawa Takashi
中科院分区：
文献类型：
--
作者：
Hori Yuki;Ihara Naoki;Sugai Chiaki;Ogura Jun;Honda Manabu;Kato Koichi;Isomura Yoshikazu;Hanakawa Takashi
自愿行动需要动机。内侧前额叶皮层（MPFC）是评估动机价值的重要区域。然而，目前还不清楚动机过程如何进入大脑中的运动执行系统。在这里，我们提出的证据表明，腹侧纹状体（VS）起着枢纽样的作用，在调解动机和运动加工的操作行为。我们使用正电子发射断层扫描（PET）来检测与动机行为相关的神经激活区域。使用所获得的区域，进行偏相关分析，以检查激励信号如何传播到运动系统。结果表明，VS活动通过丘脑传播到MPFC和初级运动皮层。此外，蝇蕈醇注射到VS抑制的动机行为，支持的动机信号在VS的代表性，触发动机行为的想法。这些结果表明，VS-丘脑通路通过与MPFC的相互作用对动机处理和通过与运动BG回路的相互作用对运动处理都起着关键作用。
Voluntary actions require motives. It is already known that the medial prefrontal cortex (MPFC) assess the motivational values. However, it remains unclear how the motivational process gains access to the motor execution system in the brain. Here we present evidence that the ventral striatum (VS) plays a hub-like role in mediating motivational and motor processing in operant behavior. We used positron emission tomography (PET) to detect the neural activation areas associated with motivational action. Using obtained regions, partial correlation analysis was performed to examine how the motivational signals propagate to the motor system. The results revealed that VS activity propagated to both MPFC and primary motor cortex through the thalamus. Moreover, muscimol injection into the VS suppressed the motivational behavior, supporting the idea of representations of motivational signals in VS that trigger motivational behavior. These results suggest that the VS-thalamic pathway plays a pivotal role for both motivational processing through interactions with the MPFC and for motor processing through interactions with the motor BG circuits.