HYPOXEMIA DURING APNEA IN NORMAL SUBJECTS - MECHANISMS AND IMPACT OF LUNG-VOLUME
HYPOXEMIA DURING APNEA IN NORMAL SUBJECTS - MECHANISMS AND IMPACT OF LUNG-VOLUME
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DOI：
10.1152/jappl.1983.55.6.1777
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发表时间：
1983-01-01
影响因子：
3.3
通讯作者：
WAGNER, PD
中科院分区：
文献类型：
--
作者：
FINDLEY, LJ;RIES, AL;WAGNER, PD
本文研究了七名正常清醒男性在呼吸暂停时发生低氧血症的机制和肺容量的影响。在重复的30秒自主屏气，这些科目进行了研究，在不同的肺容量，在各种呼吸演习，并在坐位和仰卧位。在这些重复的呼吸保持过程中对呼出气体和动脉氧饱和度的分析得出以下结论。在正常清醒的受试者中，低肺容量下持续30秒的呼吸暂停伴有严重的动脉氧饱和度下降。初始肺容量是呼吸暂停期间低氧血症的最重要决定因素。在大多数肺容量下呼吸暂停的低氧血症可以解释为均匀肺中的单纯肺泡通气不足。在依赖性气道容易关闭的肺容量下，肺不表现为单室模型。
Seven normal awake males were studied to define the mechanisms and impact of lung volume on the hypoxemia occurring during apnea. During repeated 30-s voluntary breath holding, these subjects were studied at different lung volumes, during various respiratory maneuvers and in the sitting and supine body positions. Analysis of expired gases and arterial O2 saturation during these repeated breath holdings yielded the following conclusions. Apnea of 30-s duration at low lung volumes is accompanied by severe arterial O2 desaturation in normal awake subjects. Initial lung volume is the most important determinant of hypoxemia during apnea. The hypoxemia of apnea at most lung volumes can be explained by simple alveolar hypoventilation in a uniform lung. The lung does not behave as a single-compartment model at lung volumes at which dependent airways are susceptible to closure.