Chemistry and biological activities of CO-releasing molecules (CORMs) and transition metal complexes
Chemistry and biological activities of CO-releasing molecules (CORMs) and transition metal complexes
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DOI：
10.1039/b701992k
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发表时间：
2007-01-01
影响因子：
4
通讯作者：
Motterlini, Roberto
中科院分区：
文献类型：
--
作者：
Alberto, Roger;Motterlini, Roberto
CO作为一种小分子的出现，除了NO之外，还具有重要的生物学功能，已经开始寻找能够在生理条件下以明确的方式释放CO的化合物和复合物。由于在临床前研究中已经确定了CO的一些药理学和治疗作用，因此可以用作药物的定制CO释放分子（CORM）可以对许多患者有很大的益处。CO2的释放是化学中最常见的特征之一，并且产生NO的分子非常成熟，但具有CO释放特性的化合物很少。本文讨论了一些更有前途的候选人和正在研究的分子。此外，分子具有内在的功能，作为潜在的CO-RM和价值深入调查提出。因此，重点是主族化合物和过渡元素络合物。应该强调的是，CORM不仅作为治疗剂具有令人鼓舞的前景，而且还可能是合成含CO配体的新型配合物的重要途径。为了强调CORM的前景，化学部分嵌入生物和医学背景中。
The advent of CO as a small molecule that, in addition to NO, elicits essential biological functions has initiated the search for compounds and complexes capable of releasing CO in a well defined manner under physiological conditions. Since some pharmacological and therapeutic effects of CO have been established in preclinical studies, tailor-made CO-releasing molecules (CORMs) which could be utilized as pharmaceuticals could be of great benefit for many patients. Release of CO2 is one of the most common features in chemistry and NO producing molecules are very well established but compounds with CO-releasing properties are rare. Some of the more promising candidates and molecules under study are discussed in this article. Furthermore, molecules that possess intrinsic features to serve as potential CO-RMs and merit indepth investigations are proposed. The focus is thereby on main group compounds and on transition element complexes. It should be emphasized that CORMs not only have encouraging prospects as therapeutic agents but may also be signficant for synthetic pathways to novel complexes containing the CO ligand. To underline the prospects of CORMs, the chemical part is embedded in a biological and medicinal context.