Microparticle formation of sodium cellulose sulfate using supercritical fluid assisted atomization introduced by hydrodynamic cavitation mixer
Microparticle formation of sodium cellulose sulfate using supercritical fluid assisted atomization introduced by hydrodynamic cavitation mixer
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DOI：
10.1016/j.cej.2010.02.004
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发表时间：
2010-05
影响因子：
15.1
通讯作者：
Qi Wang;Y. Guan;Shanjing Yao;Ziqiang Zhu
中科院分区：
文献类型：
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作者：
Qi Wang;Y. Guan;Shanjing Yao;Ziqiang Zhu
采用水力空化混合器超临界流体辅助雾化技术(SAA-HCM)制备了球形好、粒径分布可控的纤维素硫酸钠(NaCS)微粒。考察了混合器温度、压力、质量流量比、沉淀器温度、溶液浓度、NaCS相对分子质量等工艺参数对沉淀物形态和粒度分布的影响。在最佳操作条件下，制得了平均粒径为0.3~3.0μm的球形NaCS粒子，并获得了较窄的粒度分布。自然地提出了放气气球的颗粒形成机制。傅立叶变换红外光谱分析表明，SAA-HCM处理后的NaCS与未处理的NaCS相比，一级结构和稳定性没有明显变化。用X射线衍射仪和热重分析法研究了NaCS的改性，发现SAA-HCM处理后，NaCS的晶态发生了轻微的变化，具有较高的热稳定性。结果表明，SAA-HCM法制备的NaCS微粉化技术有望成为一种很有前途的药物传递系统技术。
A novel micronization technique so-called supercritical fluid assisted atomization introduced by hydrodynamic cavitation mixer (SAA-HCM) was used to produce the sodium cellulose sulfate (NaCS) microparticles with well-defined spherical morphologies and controlled particle size distributions in aqueous solution. The process parameters such as mixer temperature and pressure, the mass flow ratio, precipitator temperature, solution concentration and the molecular weight of NaCS were investigated in detail to evaluate their influences on the morphologies and size distributions of precipitates. Spherical NaCS particles with mean diameters ranging from 0.3 to 3.0μm were produced at the optimum operating conditions and narrow particle size distributions were obtained. It is natural to put forward the particle formation mechanism of deflated balloons. Compared with the unprocessed NaCS, there was no significant change on the primary structure and stability of the NaCS processed by SAA-HCM verified by Fourier transform infrared spectroscopy. The X-ray diffraction and thermo-gravimetric analysis were also used to investigate NaCS modifications and a slight change in crystalline state with higher thermal stability was observed when treated by SAA-HCM process. The results indicated that NaCS micronization by SAA-HCM process was expected to be a promising technique for drug delivery system.