Firing patterns of inferior colliculus neurons-histology and mechanism to change firing patterns in rat brain slices
Firing patterns of inferior colliculus neurons-histology and mechanism to change firing patterns in rat brain slices
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DOI：
10.1016/s0304-3940(01)02425-9
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发表时间：
2002-01-04
影响因子：
2.5
通讯作者：
Sanders, DJ
中科院分区：
文献类型：
--
作者：
Bal, R;Green, GGR;Sanders, DJ
采用细胞内记录技术，对大鼠下丘中央核(CNIC)进行细胞内记录。对184个神经元进行了稳定的细胞内记录，其中27个神经元成功地被离子化的生物细胞素染色。其中21个被归类为扁平(F)，4个被归类为较少扁平(LF)，其余两个神经元被归类为未分类神经元。对去极化电流步骤的反应记录显示了五种放电模式：开始、适应(规则和不规则)、规则和突发。起病神经元呈非线性电流-电压关系，其余神经元呈线性电流-电压关系。预适应超极化改变了CNIC神经元的反应模式。结论：两者之间没有解剖学和生理学上的相关性，膜电位水平可能在某些放电模式的产生中起重要作用。(C)2002爱思唯尔科学爱尔兰有限公司。保留所有权利。
An in vitro slice preparation was used for intracellular recording from rat central nucleus of inferior colliculus neurons (CNIC). Stable intracellular recordings were made on 184 neurons, 27 of which were successfully stained with ionto-phoresed biocytin. Twenty one of those were classified as flat (F), four as less flat (LF) and the remaining two neurons as unclassified neurons. Recording in response to depolarizing current steps revealed five firing patterns: onset, adapting (regularly and irregularly), regular and bursting. The onset neurons showed non-linear current-voltage (I-V) relationship, whereas the rest had linear current-voltage relationship. Preconditioning hyperpolarizations changed the response pattern of CNIC neurons. It is concluded that there is no anatomy and physiology correlation and the levels of membrane potential may be important in the production of some firing patterns. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.