Mediation and inhibition of cell adhesion by morphoregulatory molecules.
Mediation and inhibition of cell adhesion by morphoregulatory molecules.
复制标题
形态调节分子对细胞粘附的介导和抑制。
DOI：
10.1101/sqb.1992.057.01.036
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Edelman,GM
中科院分区：
文献类型：
--
作者：
Edelman,GM
The cell surface plays a central role in regulating processes that lead to the formation of tissues and organs. These processes include the control of cell division, cell motion, adhesion, neurite extension, and embryonic induction. In the formation of a complex tissue, a remarkable set of coordinative events must occur to correlate mechanochemical changes in cell shape and mobility with cell interaction and gene expression. During the last 15 years, it has become apparent that three families of morphoregulatory molecules are centrally involved in such correlations. These include cell and substrate adhesion molecules and molecules involved in junctional complexes (Edelman et al. 1990).Analyses of these molecules have revealed a remarkable set of properties and interactions. Two main themes have emerged:(1) Distinct place-dependent patterns of expression of these molecules can be seen during morphogenesis (Edelman 1988; Edelman and Crossin 1991; Takeichi 1991) and (2) the interactions of these molecules at the cell surface couple transmembrane control via the cytoskeleton (Edelman 1976) to specific external binding events (Nagafuchi and Takeichi 1988; Jaffe et al. 1990). To comprehend how these observations can be related to morphogenesis, it is important to understand the mechanisms of various binding events and signaling pathways affecting cell adhesion, shape, and motion. It is equally important to understand the means by which the genes for morphoregulatory molecules are expressed in a placedependent manner during development. In this paper, I touch briefly on some observations bearing on these two themes. I focus on certain CAMs (cell adhesion molecules) and on an extracellular matrix molecule, cytotactin. CAMs are responsible for cell-cell adhesion. Cytotactin is an example of a molecule whose interactions tend to inhibit adhesive events and lead to various alterations of cell shape and motion. A recent analysis of the promoter region of the gene for the neural cell adhesion molecule (N-CAM) and of that for cytotactin suggests that these promoters are targets for the products of homeobox-containing genes (Jones et al. 1992a, b). Although the significance of these observations is still not fully assessed, they may provide a basis (Edelman 1992) for connecting the regional expression of morphoregulatory molecules to their mechanochemical effects on tissue patterning.
