The effect of hepatocyte growth factor on the behaviour of osteoclasts.
The effect of hepatocyte growth factor on the behaviour of osteoclasts.
复制标题
肝细胞生长因子对破骨细胞行为的影响。
DOI：
--
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
T. Chambers
中科院分区：
文献类型：
--
作者：
K. Fuller;J. Owens;T. Chambers
肝细胞生长因子（HGF）刺激包括造血祖细胞在内的多种细胞类型的生长、运动和形态发生。我们发现，肝细胞生长因子是一个有效的抑制骨吸收的大鼠破骨细胞。然而，在成骨细胞系UMR 106的存在下，它刺激骨吸收。在相似的浓度范围内，HGF也增加了骨细胞的运动性和扩散面积。我们没有发现对破骨细胞形成或存活的影响。我们的数据表明，肝细胞生长因子可能参与招募破骨细胞的骨吸收的网站，但在迁移过程中，再吸收功能受到抑制。一旦在吸收位点，破骨细胞对HGF的反应由成骨细胞调节，破骨细胞的骨吸收活性可相应地被刺激。
Hepatocyte growth factor (HGF) stimulates the growth, motility and morphogenesis of a variety of cell types, including hemopoietic progenitors. We found that HGF is a potent inhibitor of bone resorption by isolated rat osteoclasts. However, in the presence of the osteoblastic cell line UMR 106, it stimulated osteoclastic resorption. HGF also increased osteoclastic motility and spread area, over a similar concentration range. We detected no effect on osteoclast formation or survival. Our data suggest that HGF may be involved in the recruitment of osteoclasts to sites of bone resorption, but that during migration resorptive functions are suppressed. Once on resorptive sites, the osteoclast response to HGF is modulated by osteoblastic cells and the bone resorptive activity of osteoclasts may be stimulated accordingly.