Regulation of phenotypic transitions in the fungal pathogen Candida albicans.

Regulation of phenotypic transitions in the fungal pathogen Candida albicans.
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真菌病原体白色念珠菌表型转变的调节

DOI:
10.4161/viru.20010
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发表时间:
2012-05-01
期刊:
影响因子:
5.2
通讯作者:
Huang G
Huang G
中科院分区:
生物学2区
文献类型:
--
作者:
Huang G

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人类真菌白色念珠菌不仅可以引起浅表感染,而且可以在免疫功能低下的个体中引起危及生命的疾病。C.白色念珠菌可以以几种形态学形式生长。在不同表型形式之间转换的能力被认为有助于其毒力。酵母-丝状生长转变和白色-不透明转换代表了两种典型的形态转换系统,在C.白色念珠菌环境因素和基因的相互作用决定了C.白色念珠菌这篇综述着重于这种致病生物的表型变化的外部环境线索和内部基因的调节。
The human commensal fungus Candida albicans can cause not only superficial infections, but also life-threatening disease in immunocompromised individuals. C. albicans can grow in several morphological forms. The ability to switch between different phenotypic forms has been thought to contribute to its virulence. The yeast-filamentous growth transition and white-opaque switching represent two typical morphological switching systems, which have been intensively studied in C. albicans. The interplay between environmental factors and genes determines the morphology of C. albicans. This review focuses on the regulation of phenotypic changes in this pathogenic organism by external environmental cues and internal genes.
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