Regulation of phenotypic transitions in the fungal pathogen Candida albicans.
Regulation of phenotypic transitions in the fungal pathogen Candida albicans.
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真菌病原体白色念珠菌表型转变的调节
DOI:
10.4161/viru.20010
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发表时间:
2012-05-01
期刊:
影响因子:
5.2
通讯作者:
Huang G
中科院分区:
文献类型:
--
作者:
Huang G
The human commensal fungus Candida albicans can cause not only superficial infections, but also life-threatening disease in immunocompromised individuals. C. albicans can grow in several morphological forms. The ability to switch between different phenotypic forms has been thought to contribute to its virulence. The yeast-filamentous growth transition and white-opaque switching represent two typical morphological switching systems, which have been intensively studied in C. albicans. The interplay between environmental factors and genes determines the morphology of C. albicans. This review focuses on the regulation of phenotypic changes in this pathogenic organism by external environmental cues and internal genes.
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通讯作者:
Cantore, ML
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Pla, J
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通讯作者:
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Sundstrom, P
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Ernst, JF