REM sleep behavioral disorder may be an independent risk factor for orthostatic hypotension in Parkinson’s disease
REM sleep behavioral disorder may be an independent risk factor for orthostatic hypotension in Parkinson’s disease
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DOI：
10.1007/s40520-021-01887-y
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发表时间：
2021-05
影响因子：
4
通讯作者：
Kangfu Yin;Chuanbin Zhou;Yongyun Zhu;Weifang Yin;Lei Yin;Bin Liu;Hui Ren;Zhong Xu;Xinglong Yang
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作者：
Kangfu Yin;Chuanbin Zhou;Yongyun Zhu;Weifang Yin;Lei Yin;Bin Liu;Hui Ren;Zhong Xu;Xinglong Yang
目的本研究的目的是评估PD患者临床上可能的快速眼动（REM）睡眠行为障碍（pRBD）与体位性低血压（OH）之间的关联，并探讨这种关联的机制。方法PD患者（n= 116）被分配到有OH组（PD-OH）或无OH组（PD-NOH）。收集一般人口统计和临床数据。采用一系列量表评估两组的临床症状。结果共有27例患者（23.3%）患有OH。与PD-NOH组相比，PD-OH组的H-Y分期评分显着更高，pRBD、焦虑、抑郁和认知障碍的频率显着更高。二元 Logistic 回归分析确定以下因素与 PD-OH 独立相关：H-Y 分期 [比值比 (OR) 2.565，95% 置信区间 (CI) 1.160–5.673；P= 0.020]、RBD（OR 7.680，95% CI 1.944–30.346；P= 0.004）、UPDRS II （OR 1.021，95% CI 0.980–1.063；P= 0.020）、抑郁症（OR 7.601，95% CI 1.492–38.718；P= 0.015）和认知障碍（OR 0.824，95% CI 0.696–0.976;P= 0.025）。结论我们的结果表明pRBD是PD患者发生OH的独立危险因素。我们推测RBD与OH之间可能存在密切关系，需要引起重视。 RBD 的早期诊断可能有助于预测 PD 患者 OH 的出现。
PurposeThe purpose of this study was to evaluate the association between clinically possible rapid eye movement (REM) sleep behavioral disorder (pRBD) and orthostatic hypotension (OH) in PD patients, as well as to explore the mechanisms underlying the association.MethodsPD patients (n= 116) were assigned to a group with OH (PD-OH) or without OH (PD-NOH). General demographic and clinical data were collected. A series of scales were used to assess the clinical symptoms in the two groups.ResultsA total of 27 patients (23.3%) had OH. The PD-OH group showed significantly higher H-Y staging score and significantly higher frequencies of pRBD, anxiety, depression, and cognitive impairment than the PD-NOH group. Binary logistic regression analysis identified the following factors as independently associated with PD-OH: H-Y staging [odds ratio (OR) 2.565, 95% confidence interval (CI) 1.160–5.673;P= 0.020], RBD (OR 7.680, 95% CI 1.944–30.346;P= 0.004), UPDRS II (OR 1.021, 95% CI 0.980–1.063;P= 0.020), depression (OR 7.601, 95% CI 1.492–38.718;P= 0.015), and cognitive impairment (OR 0.824, 95% CI 0.696–0.976;P= 0.025).ConclusionsOur results suggest that pRBD is an independent risk factor for OH in patients with PD. We speculate that there may be a close relationship between RBD and OH, which requires attention. Early diagnosis of RBD may help predict the appearance of OH in PD patients.