Oxidative stress in airways - Is there a role for extracellular superoxide dismutase?
Oxidative stress in airways - Is there a role for extracellular superoxide dismutase?
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DOI：
10.1164/rccm.2206014
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发表时间：
2002-12-15
影响因子：
24.7
通讯作者：
Crapo, JD
中科院分区：
文献类型：
--
作者：
Bowler, RP;Crapo, JD
气道暴露在高水平的环境氧化剂中，但它们也有丰富的细胞外抗氧化剂。气道疾病，如哮喘、囊性纤维化和慢性阻塞性肺疾病有氧化应激增加的证据，表明活性氧和氮可能压倒气道疾病中的抗氧化防御。细胞外超氧化物歧化酶在肺组织中丰富，保护肺免受氧化应激的增加；然而，其在哮喘和其他气道疾病中的作用尚未完全阐明。细胞外超氧化物歧化酶的蛋白水解过程降低了其对细胞外基质的亲和力，可能是在炎症或氧化应激条件下调节其分布的机制。
Airways are exposed to high levels of environmental oxidants, yet they also have enriched extracellular antioxidants. Airways disease such as asthma, cystic fibrosis, and chronic obstructive pulmonary disease have evidence of increased oxidative stress, suggesting that reactive oxygen and nitrogen species may overwhelm antioxidant defenses in airway diseases. Extracellular superoxide dismutase Is abundant in pulmonary tissues and protects the lung from increased oxidative stress; however, its rote in asthma and other airway diseases has not been fully elucidated. Proteolytic processing of extracellular superoxide dismutase decreases its affinity for the extracellular matrix and may be a mechanism to regulate its distribution during conditions of inflammation or oxidative stress.