HLA and Epilepsy
HLA and Epilepsy
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HLA 和癫痫
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
D. Janz
中科院分区：
文献类型：
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作者：
M. Durner;J. Zingsem;D. Greenberg;T. Sander;D. Janz
HLA抗原与某些特定疾病的相关性给我们提供了机会，以增加我们对这些疾病的了解。在这些病因不明的疾病中，这种情况在受影响的人的家庭中比在一般人群中更频繁地发生。遗传方式一般是未知的。相关性表明至少部分遗传基础位于HLA区域。HLA区域（或MHC）位于6号染色体的短臂上，由A、B、C和D基因座组成。与这些基因座相关的是几个不参与免疫机制的基因座，如补体因子（C2、Bf、C4）和酶（磷酸葡萄糖变位酶3，PGM 3;谷胱甘肽酶1，GLO）的基因。此外，血色病（HFE）和先天性肾上腺增生（CA 21 H）的易感性基因已被定位到HLA区域本身。
The association of HLA antigens with some specific diseases has given us the opportunity to increase our understanding of these diseases. In these diseases of unknown etiology, the condition occurs more frequently in families of affected people then in the general population. The mode of inheritance is generally unknown. Association indicates that at least part of the genetic basis lies in the HLA region. The HLA region (or MHC) is located on the short arm of chromosome 6 and is composed of the A, B, C, and D locus. Linked with these loci are several loci not involved in immunological mechanisms such as genes for complement factors (C2, Bf, C4) and enzymes (phosphoglucomutase 3, PGM3; glyoxalase 1, GLO). Furthermore, the genes for susceptibility to hemochromatosis (HFE) and congenital adrenal hyperplasia (CA21 H) have been mapped to the HLA region itself.