Enhancing Coil Design for Micromagnetic Brain Stimulation
Enhancing Coil Design for Micromagnetic Brain Stimulation
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DOI：
10.1557/adv.2018.155
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发表时间：
2018-01-01
期刊：
影响因子：
0.8
通讯作者：
Deng, Jiangdong
中科院分区：
文献类型：
--
作者：
Bonmassar, Giorgio;Golestanirad, Laleh;Deng, Jiangdong
这项工作进一步推进了微磁刺激（μ MS）技术，该技术已经显示出通过亚毫米尺寸的线圈释放时变电流，在组织的聚焦区域中使用磁感应刺激神经系统的能力。然而，μ MS最初是基于商用现货（COTS）电感器，其设计目的是最大限度地提高效率并最大限度地减少其损耗，尽管屏蔽了磁场到达神经组织。在这项工作中，我们研究和制造下一代μ MS设备的微尺度线圈结构。线圈被设计为通过使用平面方形螺旋线圈几何形状来优化注入组织中的通量，该几何形状先前被证明对于神经元刺激是最佳的。所提出的μ MS装置的电磁有限元法（FEM）模拟的结果表明，即使螺旋具有完全对称的设计，其仍然在组织中的感应电场中表现出不对称性，这可以潜在地用于激活具有特定轴突取向的神经元。这种设备可以成为未来的大脑和心脏刺激器，其非接触式能力可以提供需要植入式心律转复器或起搏器的患者或帕金森病患者的治疗效果所需的神经元刺激，癫痫。
This work further advances the micromagnetic stimulation (mu MS) technology, which has shown the capability of stimulating the nervous system using magnetic induction in a focal region of tissue by discharging a time-varying current through a sub-millimeter size coil. However, mu MS was originally based on commercial off the shelf (COTS) inductors, which are designed to maximize efficiency and minimize its losses albeit shielding off the magnetic field from reaching the neural tissue. In this work, we study and fabricate microscale coil structures for next-generation mu MS devices. The coil was designed to optimize the flux injected into the tissue by using a planar square spiral coil geometry, which was previously shown to be optimal for neuronal stimulation. The results of the electromagnetic Finite Elements Method (FEM) simulations of the proposed mu MS device show that even though the spiral has a fully symmetric design, it nonetheless exhibits an asymmetry in the induced electric field in the tissue that can potentially be used for activating neurons with a specific axonal orientation. Such devices could become the brain and heart stimulators of the future with their contactless ability to deliver the neuronal stimulation needed for therapeutic efficacy in patients in need of implantable cardioverter-defibrillators or pace-makers, or patients with Parkinson's disease, epilepsy.