Overexpression of Galectin-1 is negatively correlated with pathologic differentiation grade in oral squamous cell carcinoma
Overexpression of Galectin-1 is negatively correlated with pathologic differentiation grade in oral squamous cell carcinoma
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DOI：
10.1007/s00432-010-0810-2
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发表时间：
2010-02
影响因子：
3.6
通讯作者：
L. Zhong;Kui-jie Wei;X. Yang;H. Pan;D. Ye;Li-Zhen Wang;Zhi-Yuan Zhang
中科院分区：
文献类型：
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作者：
L. Zhong;Kui-jie Wei;X. Yang;H. Pan;D. Ye;Li-Zhen Wang;Zhi-Yuan Zhang
PurposeTo determine the Galectin-1 protein expression in oral squamous cell carcinoma (OSCC).MethodsComparative proteomic analysis of an in vitro cellular carcinogenesis model of OSCC we previously established was performed to identify differentially expressed proteins. Galectin-1 was further validated in vitro (human immortalized oral epithelia cell line and OSCC lines) and in vivo (tissue samples from OSCC patients) by Western blotting and immunohistochemistry, respectively.ResultsIncreased Galectin-1 protein expression was identified in the cancerous cell line compared with the immortalized oral epithelial cell line in the in vitro cellular carcinogenesis model, and then validated in the OSCC lines and cancerous tissues. Galectin-1 protein expression was negatively correlated with the tumor pathologic differentiation grades, a higher Galectin-1 protein expression indicating a poorer pathologic differentiation grade.ConclusionsGalectin-1 protein expression level increases in OSCC, it may serve as a candidate marker for pathologic differentiation grade of OSCC.
