Birthweight of offspring and mortality of parents: The Jerusalem perinatal study cohort
Birthweight of offspring and mortality of parents: The Jerusalem perinatal study cohort
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DOI：
10.1016/j.annepidem.2007.07.099
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发表时间：
2007-11-01
影响因子：
5.6
通讯作者：
Harlap, Susan
中科院分区：
文献类型：
--
作者：
Friedlander, Yechiel;Paltiel, Ora;Harlap, Susan
目的：我们试图研究后代出生体重与其父母死亡率之间的关系。区分母亲和父亲的风险结果可能提供线索的遗传与非遗传机制的相对作用，这些协会的基础。我们研究了1964-1976年间在西耶路撒冷分娩的37,718名母亲和38,002名父亲的总死亡率和死因特异性死亡率，结果：控制社会人口学和生活方式特征的风险模型表明，后代的出生体重与母亲的总体死亡率、冠心病、循环系统疾病和其他非肿瘤原因死亡之间存在U形关系。与其子女出生时体重为2500-3999 g的母亲相比，在低出生体重（风险比[HR]，2.13; 95%置信区间[CI]，1.40-3.25）和高出生体重（HR，1.98; 95% CI，1.36-2.88）婴儿的母亲中观察到更高的冠心病死亡率。调整母体先兆子痫轻微减弱这些结果。多变量模型表明，后代的出生体重和父亲的总体死亡率之间存在负线性关系（HR，0.95; 95%CI，0.91-0.99）。与母亲的相关性不同，这种关系主要与“其他原因”造成的死亡有关。结论：后代的体重与父母死亡率有关，尽管这种关系对父亲和母亲来说是不同的。这些发现拓宽了先前的观察，即子宫内事件对成人健康有长期影响，并支持需要探索这些关联背后的遗传和/或环境机制。
PURPOSE: We sought to examine the association between birthweight in offspring and mortality in their parents. Distinguishing between risks of outcomes in mothers from fathers potentially provides clues as to the relative roles of genetic versus nongenetic mechanisms underlying these associations.METHODS: We studied total and cause-specific mortality in a population-based cohort of 37,718 mothers and 38,002 fathers whose offspring were delivered in West Jerusalem during 1964-1976, after an average follow-up of 34.12 years.RESULTS: Hazard models controlling for sociodemographic and lifestyle characteristics indicated a U-shaped relationship between offspring's birthweight and overall mortality, deaths from coronary heart disease, circulatory and other non-neoplastic causes in their mothers. Greater rates of mortality from coronary heart disease were observed among mothers who gave birth to babies with low (hazard ratio [HR], 2.13; 95% confidence interval [CI], 1.40-3.25) and high birthweight (HR, 1.98; 95% CI, 1.36-2.88), as compared with mothers whose offspring weighed 2500-3999 g at birth. Adjustment for maternal preeclampsia slightly attenuated these results. Multivariate models indicated a negative linear relationship (HR, 0.95; 95% Cl, 0.91-0.99) between offspring's birthweight and overall mortality in their fathers. Unlike the association in mothers, the relation was noted primarily with deaths from "other causes."CONCLUSIONS: Birthweight of offspring is associated with parental mortality although the relation differs for fathers and mothers. These findings broaden previous observations that intra-uterine events have long-term consequences for adult health and support the need to explore genetic and/or environmental mechanisms underlying these associations.