Mabdose: A program for the calculation of internal dose
Mabdose: A program for the calculation of internal dose
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Mabdose：计算内部剂量的程序
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
B. Berman
中科院分区：
文献类型：
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作者：
T. Johnson;G. Andl;B. Berman
在MIRD小册子11中实施的MIRD方法不容易应用于与治疗量的放射性标记抗体靶向癌症相关的剂量测定问题。MABDOSE计划就是为了解决这些问题而创建的。具体而言，它允许在参考人几何结构内交互定义放射性的任意源和目标（代表实体肿瘤）。与其他程序相比，MABDOSE将累积活度的计算集成到剂量计算环境中。该程序在Windows操作系统下运行，并使用直观的图形界面来创建代表放射性在体内运动的模型。数据库设施允许存储和调用以前验证的模型。6个参考人体模型的分辨率为1 cm{sup 3}，可选择创建其他分辨率数据集。操作员可以从磁盘中读取S值或模拟辐射传输，利用并行微处理器的集合来减少计算时间。该程序目前正在根据已发布的Mird 11 {prime}S{prime}表进行验证。MABDOSE程序提供了一个独特的计算工具，用于计算体内放射性核素剂量。
The MIRD methodology as implemented in MIRD pamphlet 11 is not easily applied to the dosimetry problems associated with the targeting of cancer by therapeutic amounts of radiolabeled antibodies. The MABDOSE program was created to address these problems. Specifically, it allows the interactive definition of arbitrary sources and targets of radioactivity (representative of solid tumors) within the Reference Man geometry. In contrast with other programs, MABDOSE Integrates the calculation of cumulated activity into the dose computation environment. The program runs under the windows operating system, and uses an intuitive graphical interface to allow the creation of models representative of the movement of radioactivity through the body. Database facilities allow the storage and recall of previously validated models. The 6 Reference Man phantoms are provided with resolution of 1 cm{sup 3}, with the option of creating other resolution data sets. The operator can either read in {prime}S{prime} values from disk or simulate radiation transport, taking advantage of a collection of parallel micro-processors to decrease computation time. The program is currently being validated against the published Mird 11 {prime}S{prime} tables. The MABDOSE program offers a unique computation tool for the calculation of internal radionuclide dosimetry.