The Effect of Four Imidazolium Ionic Liquids on Hen Egg White Lysozyme Solubility
The Effect of Four Imidazolium Ionic Liquids on Hen Egg White Lysozyme Solubility
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四种咪唑离子液体对鸡蛋清溶菌酶溶解度的影响
DOI：
10.1021/je100880a
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Zhijiang Zhou
中科院分区：
文献类型：
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作者：
Zhanzhong Wang;Huazhi Xiao;Ye Han;P. Jiang;Zhijiang Zhou
研究表明，离子液体（IL）与生物材料的一些潜在的应用。本文以1-丁基-3-甲基咪唑四氟硼酸盐（[C4 mim] BF_4）、1-丁基-3-甲基咪唑氯盐（[C4 mim]Cl）、1-丁基-3-甲基咪唑溴盐（[C4 mim]Br）和1，3-二甲基咪唑碘盐（[dmim]I）为离子液体，研究了它们对溶菌酶在pH4.5水溶液中溶解度的影响。结果表明，溶菌酶的溶解度随[C4 mim] BF 4和[C4 mimCl]浓度的增加而增加，随[C4 mim]Br浓度的增加而几乎不变。有趣的是，溶解度随着[dmim]I浓度的增加而缓慢降低。在恒定添加的IL浓度下，溶解度随着温度的升高而增加。离子液体对溶解度的影响可以归因于改变溶菌酶分子之间的相互作用。离子液体的这种效应对高质量晶体的制备和纳米晶体的发展具有重要意义。
Research shows some potential applications for ionic liquids (ILs) with biomaterials. In this work, the ILs 1-butyl-3-methylimidazolium tetrafluoroborate ([C4mim]BF4), 1-butyl-3-methylimidazolium chloride ([C4mim]Cl), 1-butyl-3-methylimidazolium bromide ([C4mim]Br), and 1,3-dimethylimidazolium iodine ([dmim]I) were employed to investigate their effects on the solubility of lysozyme in aqueous solutions at pH 4.5. The results demonstrate that lysozyme solubility increases with the addition concentration of [C4mim]BF4 and [C4mimCl] and is nearly invariable with the increase of the [C4mim]Br concentration. Interestingly, the solubility slowly decreases with the increase of [dmim]I concentration. At constant added IL concentration, the solubility increases with increasing temperature. The effect of ILs on solubility can be attributed to changing interaction among lysozyme molecules. The effect of ILs employed in this work may provide crucial insight into the preparation of high-quality crystals and the develo...