Nonsteroidal anti-inflammatory agents in the therapy for experimental pneumococcal meningitis.
Nonsteroidal anti-inflammatory agents in the therapy for experimental pneumococcal meningitis.
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非甾体抗炎药治疗实验性肺炎球菌脑膜炎。
DOI：
10.1093/infdis/155.5.985
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Tomasz,A
中科院分区：
文献类型：
--
作者：
Tuomanen,E;Hengstler,B;Rich,R;Bray,MA;Zak,O;Tomasz,A
细菌性脑膜炎时蛛网膜下腔炎性肿块增加可能与疾病预后不良有关。使用肺炎球菌脑膜炎的兔子模型，我们试图减少这种炎症过程。当动物用花生四烯酸代谢的环氧合酶途径抑制剂治疗时，肺炎球菌细胞壁导致死亡和产生白细胞增多和脑脊液中异常化学的能力被阻止。氨苄青霉素引起的细菌裂解导致细胞壁释放，导致脑膜炎症显著、短暂增加。同时给予环氧合酶抑制剂和抗生素也可防止这种炎症爆发。
An increased inflammatory mass in the subarachnoid space during bacterial meningitis may correlate with a poor outcome of disease. Using a rabbit model of pneumococcal meningitis, we sought to reduce this inflammatory process. The ability of the pneumococcal cell wall to cause death and to generate leukocytosis and abnormal chemistry in cerebrospinal fluid was prevented when animals were treated with inhibitors of the cyclooxygenase pathway of arachidonate metabolism. Bacterial lysis by ampicillin led to release of cell wall that caused a significant, transient increase in meningeal inflammation. This inflammatory burst was also prevented by administering cyclooxygenase inhib-itors concurrently with the antibiotic.