Circulating vascular endothelial growth factors and their soluble receptors in pre-invasive, invasive and recurrent cervical cancer.
Circulating vascular endothelial growth factors and their soluble receptors in pre-invasive, invasive and recurrent cervical cancer.
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发表时间：
2009-02
影响因子：
2
通讯作者：
S. Kuemmel;Anke Thomas;S. Landt;Andrea Fuger;P. Schmid;M. Kriner;J. Blohmer;J. Sehouli;Gerhard Sch
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作者：
S. Kuemmel;Anke Thomas;S. Landt;Andrea Fuger;P. Schmid;M. Kriner;J. Blohmer;J. Sehouli;Gerhard Sch
目的探讨血管内皮生长因子-A、-C、-D及其可溶性受体VEGFR-1/-2在宫颈浸润性癌(CIN)、浸润性宫颈癌(PCC)和复发性宫颈癌(RCC)中的表达及其在疾病侵袭和进展中的作用。患者和方法收集125例患者治疗前的血样，其中CIN 50例，PCC51例，RCC 24例。用双抗体夹心法测定S的血清可溶性生物标志物水平，并与组织病理学因素进行相关性分析。结果随着疾病的进展，sVEGFA(p=0.007)和sVEGFR-2(p=0.014)显著升高，sVEGFR-D(p=0.046)下降。SVEGFR-2水平在淋巴结阳性组(P=0.024)和转移性疾病组(P=0.003)升高。人乳头瘤病毒阳性组sVEGFA水平较高(p=0.019)。在检测肿瘤侵袭性方面，sVEGFR-1、sVEGFR-1和sVEGFR-2的敏感性和特异性分别为76%和48%、52%和32%、25%和94%、93%和6%、73%和34%。结论在宫颈肿瘤中，随着疾病的进展，由淋巴管生成表型向血管生成表型的转变。然而，敏感度和特异度似乎不足以令人信服地将这些因素作为宫颈癌疾病侵袭性的临床标志。
AIM To study the impact of circulating vascular endothelial growth factors (VEGF) -A, -C and -D and their soluble receptors VEGFR-1/-2 on disease invasion and progression in patients with pre-invasive (CIN), invasive (PCC) and recurrent (RCC) cervical cancer. PATIENTS AND METHODS Blood samples were obtained from 125 women, including 50 cases of CIN, 51 of PCC and 24 of RCC, before treatment. Soluble (s) biomarker levels were determined by ELISA and tested for correlation with histopathological factors. RESULTS With disease progression, sVEGF-A (p = 0.007) and sVEGFR-2 (p = 0.014) significantly increased, while sVEGF-D (p = 0.046) decreased. sVEGFR-2 levels were increased in node+ patients (p = 0.024) and in metastatic disease (p = 0.003). sVEGF-A values were higher in HPV+ cases (p = 0.019). In detecting disease invasiveness, sensitivity and specificity were 76% and 48% for sVEGF-A, 52% and 32% for sVEGF-D, 25% and 94% for sVEGF-C, 93% and 6% for sVEGFR-1 and 73% and 34% for sVEGFR-2, respectively. CONCLUSION In cervical neoplasia, a switch from a lymphangiogenic phenotype towards a hemangiogenic phenotype occurs with disease invasion and progression. The sensitivity and specificity values, however, seem not convincing enough to establish these factors as clinical markers for disease invasiveness in cervical cancer.