Immediate changes in anticipatory activity of caudate neurons associated with reversal of position-reward contingency.
Immediate changes in anticipatory activity of caudate neurons associated with reversal of position-reward contingency.
复制标题
尾状神经元预期活动的立即变化与位置奖励意外事件的逆转相关。
DOI：
10.1152/jn.00012.2005
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发表时间：
2005
影响因子：
2.5
通讯作者：
Hikosaka,Okihide
中科院分区：
文献类型：
--
作者：
Watanabe,Katsumi;Hikosaka,Okihide
灵长类动物尾状核在将认知/动机信息转化为眼动信号方面起着至关重要的作用。尾状核投射神经元的一个子集在视觉目标出现之前就被激发了。这种预期活动是敏感的位置奖励的突发事件，并与眼跳潜伏期，这是较短的奖励位置。我们记录了尾状核投射神经元的单单位活动，以研究位置奖励应急开关后预期活动的动态变化。两只猴子进行视觉引导扫视任务，其中只有一个位置与奖励相关。位置-奖励映射在一个区块内保持不变，但在区块之间经常颠倒，没有任何指示给猴子。因此，只有通过意外的奖励传递或意外的奖励缺乏才能检测到转换。转换后，无论第一次试验是否得到奖励，扫视潜伏期和预期活动在第二次试验中都显示出可靠的变化。然而，在第二次试验中的预期活动普遍较高，如果第一次试验得到奖励，和测量的眼跳lastness可以更好地解释两个尾状核之间的预期活动的差异。我们认为，尾状核神经元的预期活动反映了奖励-位置偶然性的逆转集。
The primate caudate nucleus plays a crucial role in transforming cognitive/motivational information into eye movement signals. A subset of caudate projection neurons fire before a visual target's onset. This anticipatory activity is sensitive to position-reward contingencies and correlates with saccade latency, which is shorter toward a rewarded position. We recorded single-unit activity of caudate projection neurons to examine the dynamics of change in anticipatory activity immediately after switches of the position-reward contingency. Two monkeys performed a visually guided saccade task where only one position was associated with reward. The position-reward mapping remained constant within a block, but was reversed frequently between blocks without any indication to the monkey. Therefore the switch could be detected only by unexpected reward delivery or unexpected lack of reward. After the switch, both saccade latency and anticipatory activity showed reliable changes already in the second trial, whether or not the first trial was rewarded. However, anticipatory activity in the second trial was generally higher if the first trial was rewarded, and the measured saccade latencies could be better explained by the difference in anticipatory activity between the two caudate nuclei. We suggest that anticipatory activity of caudate neurons reflects the reversal set of reward-position contingency.