The epidermal growth factor receptor in Drosophila eye development.
The epidermal growth factor receptor in Drosophila eye development.
复制标题
果蝇眼睛发育中的表皮生长因子受体。
DOI：
10.1007/978-3-540-45398-7_5
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发表时间：
2002
影响因子：
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通讯作者：
Kumar,JustinP
中科院分区：
文献类型：
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作者：
Kumar,JustinP
表皮生长因子受体（Epidermal Growth Factor Receptor，Egfr）在果蝇等无脊椎动物和人、鼠等脊椎动物的发育过程中参与了大量的发育过程，几乎每个月都有新的报道报道描述Egfr通路在新的发育环境中的未知作用。已显示Egfr途径在（除其他外）细胞命运指定、细胞增殖、细胞周期控制、细胞维持、程序性细胞死亡、模式形成和器官发育中起作用。此外，改变该途径的活性和/或表达的突变已被证明是人类广泛癌症领域的根本原因。Egfr途径的无数作用既是一种祝福，也是一种诅咒，因为虽然它似乎为研究受体提供了无限的机会，但通常很难将受体的哪种功能归因于观察到的表型。果蝇复眼的简单结构和定型发育使其成为研究Egfr通路和解开其许多功能中的每一个的有吸引力的模型系统。这篇综述的目的是（1）总结已知的Egfr信号在细胞命运和细胞死亡中的作用，（2）描述Egfr在早期眼发育中的作用的最新令人兴奋的结果。
The Epidermal Growth Factor Receptor (Egfr) has been implicated in an extraordinarily vast number of developmental processes during the development of both invertebrates such as the fruit fly and vertebrates such as mouse and man. Hardly a month goes by without a new report surfacing that describes hitherto unknown roles for the Egfr pathway in new developmental contexts. The Egfr pathway has been shown to function in (among other things) cell fate specification, cell proliferation, cell cycle control, cell maintenance, programmed cell death, pattern formation and organ development. Furthermore, mutations that alter the activity and/or expression of this pathway have been shown to be the underlying cause for a wide ranging field of cancers within humans. This myriad of roles for the Egfr pathway is both a blessing and a curse in that, while it seemingly provides an unending set of opportunities to study the receptor, it is often difficult to attribute which function of the receptor is responsible for the observed phenotype. The simple structure and stereotyped development of the fly compound eye makes it an attractive model system for studying the Egfr pathway and untangling each of its many functions from one another. The goal of this review is to (1) summarize what is known about the established roles of Egfr signaling in cell fate specification and cell death and (2) to describe recent exciting results on the role of the Egfr in early eye development.